2-(tert-butoxy)-1,3,5-trimethylbenzene | 61248-61-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(tert-butoxy)-1,3,5-trimethylbenzene
• 英文别名: tert.-Butyl-mesityl-ether；Benzene, 2-(1,1-dimethylethoxy)-1,3,5-trimethyl-；1,3,5-trimethyl-2-[(2-methylpropan-2-yl)oxy]benzene
• CAS: 61248-61-1
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: CXOPJFKSVOKFDU-UHFFFAOYSA-N

物化性质

• 沸点：
  253.5±9.0 °C(Predicted)
• 密度：
  0.907±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  均三甲苯 在 碘 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 40.0h， 生成 2-(tert-butoxy)-1,3,5-trimethylbenzene
  参考文献：
  名称：

  立体拥挤的烷基芳基醚的轻度合成

  摘要：

  提出了一种通过叔醇与邻位取代的二芳基碘鎓盐的芳基化反应来获得叔烷基芳基醚的有效且无过渡金属的方法。范围包括环状和无环脂族，苄基，烯丙基和炔丙基叔醇，以及伯和仲氟化醇。该方法使人们可以获得以前前所未有的空间拥塞的烷基芳基醚。此外，通过药物前体雌二醇的芳基化证明了所开发方法的多功能性。

  DOI：

  10.1021/acs.orglett.6b01975

文献信息

• Aryl(TMP)iodonium Tosylate Reagents as a Strategic Entry Point to Diverse Aryl Intermediates: Selective Access to Arynes
  作者：Aleksandra Nilova、Bryan Metze、David R. Stuart

  DOI：10.1021/acs.orglett.1c01534

  日期：2021.6.18

  Arenes are broadly found motifs in societally important molecules. Access to diverse arene chemical space is critically important, and the ability to do so from common reagents is highly desirable. Aryl(TMP)iodonium tosylates provide one such access point to arene chemical space via diverse aryl intermediates. Here we demonstrate that controlling reaction pathways selectively leads to arynes with a

  芳烃是广泛存在于社会重要分子中的基序。进入不同的芳烃化学空间至关重要，并且非常希望能够从普通试剂中做到这一点。甲苯磺酸芳基（TMP）碘鎓通过多种芳基中间体为芳烃化学空间提供了一个这样的接入点。在这里，我们证明控制反应途径选择性地导致芳烃具有广泛的芳烃和亲芳烃（24 个例子，平均产率 70%）和有效获取生物活性化合物。
• Reactions of cyclohexadienones. 37. Attack of Grignard and lithium reagents at carbonyl oxygens of o-quinol acetates
  作者：Bernard Miller

  DOI：10.1021/jo00428a030

  日期：1977.4
• ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
  申请人：UNIVERSAL DISPLAY CORPORATION

  公开号：US20220393117A1

  公开（公告）日：2022-12-08

  Compounds of Formula I, and Formula IIa, Formula IIb, are provided. In these structures, M is Pt or Pd; each of X 1 to X 6 , X 9 to X 12 , and Z 1 to Z 3 is C or N; each of L 1 , L 2 , L 3 , and L 4 is a direct bond or a linker; at least three of L 1 , L 2 , L 3 , and L 4 are present; each K 1 , K 2 , and K 3 is a bond, O, or S; when Z 1 is N, ring A in Formula I is not a pyridine or pyrazole; L 5 is a bond or an organic linker; Y is selected from the group consisting of amino, alkoxy, aryloxy, or SiR 1 R 2 R 3 ; when Y is SiR 1 R 2 R 3 , L 2 is not BR. Devices, consumer products, and formulations containing these compounds are also disclosed.
• [EN] POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES<br/>[FR] BIOMATÉRIAUX POLYMÈRES DÉRIVÉS DE MONOMÈRES PHÉNOLIQUES ET LEURS UTILISATIONS MÉDICALES
  申请人：UNIV RUTGERS

  公开号：WO2017111994A1

  公开（公告）日：2017-06-29

  Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
• Mild Synthesis of Sterically Congested Alkyl Aryl Ethers
  作者：Erik Lindstedt、Elin Stridfeldt、Berit Olofsson

  DOI：10.1021/acs.orglett.6b01975

  日期：2016.9.2

  arylation of tertiary alcohols with ortho-substituted diaryliodonium salts. The scope covers cyclic and acyclic aliphatic, benzylic, allylic, and propargylic tertiary alcohols as well as primary and secondary fluorinated alcohols. The methodology gives access to alkyl aryl ethers of previously unprecedented steric congestion. Furthermore, the versatility of the developed procedure was demonstrated by arylation

  提出了一种通过叔醇与邻位取代的二芳基碘鎓盐的芳基化反应来获得叔烷基芳基醚的有效且无过渡金属的方法。范围包括环状和无环脂族，苄基，烯丙基和炔丙基叔醇，以及伯和仲氟化醇。该方法使人们可以获得以前前所未有的空间拥塞的烷基芳基醚。此外，通过药物前体雌二醇的芳基化证明了所开发方法的多功能性。