5-methoxy-2-methylphenyl-3'-methoxyphenylamine | 197156-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-methoxy-2-methylphenyl-3'-methoxyphenylamine
• 英文别名: 5-methoxy-N-(3-methoxyphenyl)-2-methylaniline
• CAS: 197156-25-5
• 化学式: C₁₅H₁₇NO₂
• 分子量: 243.305
• InChiKey: JBDAJVKTLVVHFM-UHFFFAOYSA-N

物化性质

• 沸点：
  366.8±37.0 °C(Predicted)
• 密度：
  1.107±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methoxy-2-methylphenyl-3'-methoxyphenylamine 在 吡啶 、 氢氧化钾 、 三氯化铝 、 氯化铵 、 对甲苯磺酰氯 、 锌 作用下， 以 异丙醇 为溶剂， 反应 29.92h， 生成 (2,3,6-trifluorophenyl) 1,6-dimethoxy-4-methyl-9,10-dihydroacridine-9-carboxylate
  参考文献：
  名称：

  Characterization of Acridancarboxylic Acid Derivatives as Chemiluminescent Peroxidase Substrates

  摘要：

  A new class of peroxidase substrates has been developed which produces chemiluminescence upon enzymatic oxidation. A wide variety of N-alkylacridancarboxylic acid derivatives including esters, thioesters, and sulfonamides are efficiently oxidized by a peroxidase and a peroxide to enzymatically produce the corresponding chemiluminescent acridinium compound, In conjunction with a peroxidase enhancer, continuous light emission with high light intensities and an extended duration are produced, Alternately, an appropriately designed acridan substrate produces a stable acridinium ester intermediate which can be accumulated and the chemiluminescence elicited as a burst of light by raising the pH. The effects of leaving groups and substitution on the acridan ring on the mechanism of light production are discussed, Peroxidase-catalyzed oxidation in the presence of a peroxide permits the detection of enzyme with subattomolar sensitivity and a broad linear dynamic range.

  DOI：

  10.1021/jo970202m
• 作为产物：
  描述：

  5-甲氧基-2-甲基苯胺 在 氢氧化钾 、 copper(l) iodide 、 potassium carbonate 、 锌 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 生成 5-methoxy-2-methylphenyl-3'-methoxyphenylamine
  参考文献：
  名称：

  Characterization of Acridancarboxylic Acid Derivatives as Chemiluminescent Peroxidase Substrates

  摘要：

  A new class of peroxidase substrates has been developed which produces chemiluminescence upon enzymatic oxidation. A wide variety of N-alkylacridancarboxylic acid derivatives including esters, thioesters, and sulfonamides are efficiently oxidized by a peroxidase and a peroxide to enzymatically produce the corresponding chemiluminescent acridinium compound, In conjunction with a peroxidase enhancer, continuous light emission with high light intensities and an extended duration are produced, Alternately, an appropriately designed acridan substrate produces a stable acridinium ester intermediate which can be accumulated and the chemiluminescence elicited as a burst of light by raising the pH. The effects of leaving groups and substitution on the acridan ring on the mechanism of light production are discussed, Peroxidase-catalyzed oxidation in the presence of a peroxide permits the detection of enzyme with subattomolar sensitivity and a broad linear dynamic range.

  DOI：

  10.1021/jo970202m

文献信息

• US5670644A
  申请人：——

  公开号：US5670644A

  公开（公告）日：1997-09-23
• US5723295A
  申请人：——

  公开号：US5723295A

  公开（公告）日：1998-03-03
• Characterization of Acridancarboxylic Acid Derivatives as Chemiluminescent Peroxidase Substrates
  作者：Hashem Akhavan-Tafti、Renuka DeSilva、Zahra Arghavani、Robert A. Eickholt、Richard S. Handley、Barry A. Schoenfelner、Katsuaki Sugioka、Yumiko Sugioka、A. Paul Schaap

  DOI：10.1021/jo970202m

  日期：1998.2.1

  A new class of peroxidase substrates has been developed which produces chemiluminescence upon enzymatic oxidation. A wide variety of N-alkylacridancarboxylic acid derivatives including esters, thioesters, and sulfonamides are efficiently oxidized by a peroxidase and a peroxide to enzymatically produce the corresponding chemiluminescent acridinium compound, In conjunction with a peroxidase enhancer, continuous light emission with high light intensities and an extended duration are produced, Alternately, an appropriately designed acridan substrate produces a stable acridinium ester intermediate which can be accumulated and the chemiluminescence elicited as a burst of light by raising the pH. The effects of leaving groups and substitution on the acridan ring on the mechanism of light production are discussed, Peroxidase-catalyzed oxidation in the presence of a peroxide permits the detection of enzyme with subattomolar sensitivity and a broad linear dynamic range.