(+/-)-oct-7-en-4-yn-3-ol | 101581-27-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+/-)-oct-7-en-4-yn-3-ol
• 英文别名: oct-7-en-4-yn-3-ol；Oct-7-en-4-in-3-ol；Oct-7-en-4-yn-3-ol
• CAS: 101581-27-5
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: PDQRZPDOTXUERO-UHFFFAOYSA-N

物化性质

• 沸点：
  68.5 °C(Press: 6 Torr)
• 密度：
  0.899 g/cm3(Temp: 10 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+/-)-oct-7-en-4-yn-3-ol 在 sodium hydroxide 作用下， 生成 octa-4,5,7-trien-3-ol
  参考文献：
  名称：

  A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy

  摘要：

  项目号：DX-20231205-19 英/汉双语对照表 翻译完毕。 本次翻译由专业翻译公司提供服务。

  DOI：

  10.1038/sj.bjp.0704606

  作为产物：

  描述：

  乙基乙炔基甲醇 、 3-溴丙烯 在 copper(l) iodide 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 以93%的产率得到(+/-)-oct-7-en-4-yn-3-ol

  参考文献：

  名称：

  通过串联尼古拉斯反应/开环易位的立体选择性合成八元环醚：（+）-顺-Lauthisan的短合成。

  摘要：

  由相应的Co2（CO）6-环烯基醚制备顺式2,8-二取代的氧杂环丁烷和母体不饱和前体。此类合成的关键步骤是通过分子间尼古拉斯反应形成醚键，合适的无环二烯基醚的RCM和蒙脱石K-10诱导的复合环炔的异构化。描述了利用开发的方法对（+）-顺-月桂聚糖的简短合成。

  DOI：

  10.1021/ol052932j

  文献信息

  • A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy
    作者：H C Doheny、M A Whittington、J G R Jefferys、P N Patsalos

    DOI：10.1038/sj.bjp.0704606

    日期：2002.3

    The tetanus toxin seizure model, which is associated with spontaneous and intermittent generalized and non‐generalized seizures, is considered to reflect human complex partial epilepsy. The purpose of the present study was to investigate and compare the anticonvulsant effects of carbamazepine with that of levetiracetam, a new anti‐epileptic drug in this model. One μl of tetanus toxin solution (containing 12 mLD50 μl−1 of tetanus toxin) was placed stereotactically into the rat left hippocampus resulting in generalized and non‐generalized seizures. Carbamazepine (4 mg kg−1 h−1) and levetiracetam (8 and 16 mg kg−1 h−1) were administered during a 7 day period via an osmotic minipump which was placed in the peritoneal cavity. Carbamazepine (4 mg kg−1 h−1) exhibited no significant anticonvulsant effect, compared to control, when the entire 7 day study period was evaluated but the reduction in generalized seizures was greater (35.5%) than that for non‐generalized seizures (12.6%). However, during the first 2 days of carbamazepine administration a significant reduction in both generalized seizure frequency (90%) and duration (25%) was observed. Non‐generalized seizures were unaffected. This time‐dependent anticonvulsant effect exactly paralleled the central (CSF) and peripheral (serum) kinetics of carbamazepine in that steady‐state concentrations declined over time, with the highest concentrations achieved during the first 2 days. Also there was a significant 27.3% reduction in duration of generalized seizures during the 7 day study period (P=0.0001). Levetiracetam administration (8 and 16 mg kg−1 h−1) was associated with a dose‐dependent reduction in the frequency of both generalized (39 v 57%) and non‐generalized (36 v 41%) seizures. However, seizure suppression was more substantial for generalized seizures. Also a significant dose‐dependent reduction in overall generalized seizure duration was observed. These data provide experimental evidence for the clinical efficacy of levetiracetam for the management of patients with complex partial seizures. Furthermore, levetiracetam probably does not act by preventing ictogenesis per se but acts to reduce seizure severity and seizure generalization. British Journal of Pharmacology (2002) 135, 1425–1434; doi:10.1038/sj.bjp.0704606

  项目号：DX-20231205-19 英/汉双语对照表 翻译完毕。 本次翻译由专业翻译公司提供服务。

  Stereoselective Synthesis of Eight-Membered Cyclic Ethers by Tandem Nicholas Reaction/Ring-Closing Metathesis:  A Short Synthesis of (+)-<i>cis</i>-Lauthisan

  作者：Nuria Ortega、Tomás Martín、Víctor S. Martín

  DOI：10.1021/ol052932j

  日期：2006.3.2

  unsaturated precursors were prepared from the corresponding Co2(CO)6-cycloalkynic ethers. Key steps in such synthesis were the ether linkage formation by intermolecular Nicholas reaction, RCM of the suitable acyclic dienyl ether and montmorillonite K-10 induced isomerization of the complexed cycloalkyne. A short synthesis of (+)-cis-lauthisan taking advantage of the developed methodology is described

  由相应的Co2（CO）6-环烯基醚制备顺式2,8-二取代的氧杂环丁烷和母体不饱和前体。此类合成的关键步骤是通过分子间尼古拉斯反应形成醚键，合适的无环二烯基醚的RCM和蒙脱石K-10诱导的复合环炔的异构化。描述了利用开发的方法对（+）-顺-月桂聚糖的简短合成。

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