2-甲基戊酸酐 | 63169-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-甲基戊酸酐
• 英文名称: 2-methylpentanoic anhydride
• 英文别名: 2-methylpentanoyl 2-methylpentanoate
• CAS: 63169-61-9
• 化学式: C₁₂H₂₂O₃
• 分子量: 214.305
• InChiKey: NCYCWNILADFMPI-UHFFFAOYSA-N

物化性质

• 沸点：
  65 °C(Press: 0.05 Torr)
• 密度：
  0.940±0.06 g/cm3(Predicted)
• 保留指数：
  1347.5

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  环丙沙星 、 2-甲基戊酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 生成 1-Cyclopropyl-6-fluoro-7-[4-(2-methylpentanoyl)piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Studies on the antimicrobial properties of N-acylated ciprofloxacins

  摘要：

  Fluoroquinolone antibiotics have been a mainstay in the treatment of bacterial diseases. The most notable representative, ciprofloxacin, possesses potent antimicrobial activity; however, a rise in resistance to this agent necessitates development of novel derivatives to prolong the clinical lifespan of these antibiotics. Herein we have synthesized and analyzed the antimicrobial properties of a library of N-acylated ciprofloxacin analogues. We find that these compounds are broadly effective against Gram-positive and Gram-negative bacteria, with many proving more effective than the parental drug, and several possessing MICs <= 1.0 mu g/ml against methicillin-resistant Staphylococcus aureus and Bartonella species. An analysis of spontaneous mutation frequencies reveals very low potential for resistance in MRSA compared to existing fluoroquinolones. Mode of action profiling reveals that modification of the piperazinyl nitrogen by acylation does not alter the effect of these molecules towards their bacterial target. We also present evidence that these N-acylated compounds are highly effective at killing intracellular bacteria, suggesting the suitability of these antibiotics for therapeutic treatment. (c) 2012 Published by Elsevier

  DOI：

  10.1016/j.bmcl.2012.05.026
• 作为产物：
  描述：

  2-甲基戊酸 在 二碳酸二叔丁酯 、 magnesium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以19 g的产率得到2-甲基戊酸酐
  参考文献：
  名称：

  [EN] NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
  [FR] NOUVEAUX COMPOSÉS SULFONIMIDOYLPURINONE ET DÉRIVÉS POUR LE TRAITEMENT ET LA PROPHYLAXIE D'INFECTION VIRALE

  摘要：

  本发明涉及式(I)的化合物，其中R1、R2和R3如本文所述，以及它们的前药或药用可接受的盐、对映体或二对映体，以及包括这些化合物的组合物和使用这些化合物的方法。

  公开号：

  WO2016180695A1

文献信息

• [EN] PROCESS FOR THE PRODUCTION OF DIACYL PEROXIDES<br/>[FR] PROCÉDÉ DE PRODUCTION DE PEROXYDES DE DIACYLE
  申请人：NOURYON CHEMICALS INT BV

  公开号：WO2020249688A1

  公开（公告）日：2020-12-17

  Process for the production of a diacyl peroxide involving the reaction of an anhydride with hydrogen peroxide, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.

  生产二酰过氧化物的过程涉及酐与过氧化氢的反应，去除形成的羧酸，从所述羧酸生产酐，并在过程中循环使用酐。
• 2,5-DIOXOIMIDAZOLIDIN-1-YL-3-PHENYLUREA DERIVATIVES AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS
  申请人：Allergan, Inc.

  公开号：US20130123215A1

  公开（公告）日：2013-05-16

  The present invention relates to novel 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

  本发明涉及新颖的2,5-二氧代咪唑啉-1-基-3-苯基脲衍生物，其制备方法，含有它们的药物组合物以及它们作为药物的用途，作为N-甲酰肽受体类似物-1（FPRL-1）受体的调节剂。
• [EN] ALPHA HELIX MIMETICS AND METHODS RELATING THERETO<br/>[FR] MIMÉTIQUES D'HÉLICE ALPHA ET PROCÉDÉS S'Y RAPPORTANT
  申请人：PRISM BIOLAB CORP

  公开号：WO2012115286A1

  公开（公告）日：2012-08-30

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  α-螺旋拟态结构和由式(I)表示的化合物，其中一般式和每个符号的定义如规范中所定义，涉及的化合物以及涉及的方法被披露。还披露了这些化合物在治疗医疗状况（例如癌症疾病、纤维化疾病）中的应用，以及包含这些拟态体的药物组合物。
• PROCESSES FOR PREPARING 4-METHYL-5-NONANONE AND 4-METHYL-5-NONANOL
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20200199052A1

  公开（公告）日：2020-06-25

  The present invention provides a process for preparing 4-methyl-5-nonanone of the following formula (3): the process comprising at least a step of subjecting 2-methylpentanoic anhydride of the following formula (1) and an n-butyl nucleophilic reagent of the following general formula (2) in which M represents Li, MgZ 1 , or ZnZ 1 , wherein Z 1 represents a halogen atom or an n-butyl group, to a nucleophilic substitution. reaction Coproduce 4-methyl-5-nonanone (3), as well as a process for preparing 4-methyl-5-nonanol of the following formula (5), the process comprising at least steps of preparing 4-methyl-5-nonanone; and subjecting the obtained 4-methyl-5-nonanone and a reducing agent to a reduction reaction to produce 4-methyl-5-nonanol (5).

  本发明提供了一种制备下式（3）的4-甲基-5-壬酮的方法：所述方法包括至少一步，即将下式（1）的2-甲基戊二酸酐和下式（2）的n-丁基亲核试剂进行亲核取代反应，其中M代表Li、MgZ1或ZnZ1，Z1代表卤原子或n-丁基团。同时提供了一种制备下式（5）的4-甲基-5-壬醇的方法，该方法包括至少以下步骤：制备4-甲基-5-壬酮；将所得的4-甲基-5-壬酮和还原剂进行还原反应以生成4-甲基-5-壬醇（5）。
• METHOD FOR PRODUCING CYCLIC SULFONIC ACID ESTER AND INTERMEDIATE THEREOF
  申请人：Kuramoto Ayako

  公开号：US20120130089A1

  公开（公告）日：2012-05-24

  The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.

  本发明旨在提供一种高效的生产方法，该方法不仅能够以低成本和高产率获得环状磺酸酯（磺酮），而且能够在商业规模下稳定地生产磺酸酯（磺酮）。本发明涉及一种生产羟基磺酮的方法，包括第一步，其中将具有特定结构的二元醇和硫酰卤反应，以获得具有特定结构的环状亚磺酸酯，以及第二步，其中将环状亚磺酸酯与水或/和醇反应；一种生产具有特定结构的不饱和磺酮的方法，包括第三步，其中将具有特定结构的羟基磺酮与酸卤或酸酐反应，以获得中间体，随后用碱处理中间体；以及具有特定结构的环状亚磺酸酯。