diethylene triamine pentaacetate tetraethyl ester | 217653-52-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethylene triamine pentaacetate tetraethyl ester
• 英文别名: DTPATE；2-[2-[2-[Bis(2-ethoxy-2-oxoethyl)amino]ethyl-(2-ethoxy-2-oxoethyl)amino]ethyl-(2-ethoxy-2-oxoethyl)amino]acetic acid
• CAS: 217653-52-6
• 化学式: C₂₂H₃₉N₃O₁₀
• 分子量: 505.566
• InChiKey: BBPASXNYUGOLSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  35
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  152
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  diethylene triamine pentaacetate tetraethyl ester 在 钯 盐酸 、 氢气 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 甲醇 、 氯仿 、 乙腈 为溶剂， 反应 40.0h， 生成
  参考文献：
  名称：

  Synthesis of Conjugated Diacetylene, Metal-Chelating Monomers for Polymerizable Monolayer Assemblies

  摘要：

  [GRAPHICS]Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal chelating SAM. It has also been demonstrated that polymerized SAMs are much more stable than non polymerized counterparts. We report herein, the synthesis of several polymerizable, metal-chelating thiols capable of complexing luminescent lanthanide ions.

  DOI：

  10.1021/ol015931+
• 作为产物：
  描述：

  diethylenetriaminepentaacetic acid pentaethyl ester 在 copper dichloride 氢氧化钾 、 水 、 硫化氢 作用下， 反应 2.0h， 以58%的产率得到diethylene triamine pentaacetate tetraethyl ester
  参考文献：
  名称：

  Method for manufacturing diethylene triamine pentaacetic acid derivative

  摘要：

  该发明首先制备五烷基DTPA，然后在使用金属离子作为催化剂的情况下对五烷基DTPA进行区域选择性水解处理，从而获得四烷基DTPA，通过上述两个步骤，制造出一种单反应性DTPA衍生物。

  公开号：

  US20060264669A1

文献信息

• Phosphorescent dye and phosphorescence immunoassay by peptide displacement
  申请人：Universität Leipzig

  公开号：EP2730574A1

  公开（公告）日：2014-05-14

  The present invention relates to a method for preparation of a 2-chloro-1,10-phenanthrolinamine, comprising the steps: i) conversion of a 2-chloro-1,10-phenanthroline to a 2-chloro-nitro-1,10-phenanthroline characterized by a formula 2, j) hydrogenation of said 2-chloro-nitro-1,10-phenanthroline characterized by formula 5 to a 2-chloro-1,10-phenanthrolinamine characterized by formula 3. The present invention relates further to a method for preparation of a 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[4-[2-(isothiocyanato-1,10-phenanthrolin-2-yl)ethynyl]anilino]-2-oxo-ethyl]amino]ethyl]amino]acetic acid characterized by formula 7 and a method for quantifying a biomolecule in a sample.

  本发明涉及一种制备2-氯-1,10-苯并啉胺的方法，包括以下步骤：i) 将2-氯-1,10-苯并啉转化为具有化学式2的2-氯-硝基-1,10-苯并啉，j) 将具有化学式5的2-氯-硝基-1,10-苯并啉氢化为具有化学式3的2-氯-1,10-苯并啉胺。本发明还涉及一种制备具有化学式7的2-[2-[双(羧甲基)氨基]乙基-[2-[羧甲基-[2-[4-[2-(异硫氰酸酯基-1,10-苯并啉-2-基)乙炔基]苯胺]-2-氧代基]氨基]乙基]氨基]乙酸的方法，以及一种在样品中定量生物分子的方法。
• Burks, Eric; Koshti, Nirmal; Jacobs, Hollie, Synlett, 1998, # 11, p. 1285 - 1287
  作者：Burks, Eric、Koshti, Nirmal、Jacobs, Hollie、Gopalan, Aravamudan

  DOI：——

  日期：——
• [EN] PHOSPHORESCENT DYE AND PHOSPHORESCENCE IMMUNOASSAY BY PEPTIDE DISPLACEMENT<br/>[FR] COLORANT PHOSPHORESCENT ET IMMUNODOSAGE FAISANT INTERVENIR LA PHOSPHORESCENCE ET IMPLIQUANT LE DÉPLACEMENT DE PEPTIDES
  申请人：UNIVERSITÄT LEIPZIG

  公开号：WO2014072492A3

  公开（公告）日：2014-07-31
• PHOSPHORESCENT DYE AND PHOSPHORESCENCE IMMUNOASSAY BY PEPTIDE DISPLACEMENT
  申请人：UNIVERSITÄT LEIPZIG

  公开号：US20150285814A1

  公开（公告）日：2015-10-08

  The present invention relates to a method for preparation of a 2-chloro-1,10-phenanthrolinamine, comprising the steps: i) conversion of a 2-chloro-1,10-phenanthroline to a 2-chloro-nitro-1,10-phenanthroline characterized by a formula 2, j) hydrogenation of said 2-chloro-nitro-1,10-phenanthroline characterized by formula 5 to a 2-chloro-1,10-phenanthrolinaminecharacterized by formula 3. The present invention relates further to a method for preparation of a 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[4-[2-(isothiocyanato-1,10-phenanthrolin-2-yl)ethynyl]anilino]-2-oxo-ethyl]amino]ethyl]amino]acetic acidcharacterized by formula 7 and a method for quantifying a biomolecule in a sample.
• Synthesis of Conjugated Diacetylene, Metal-Chelating Monomers for Polymerizable Monolayer Assemblies
  作者：Bidhan C. Roy、Sanku Mallik

  DOI：10.1021/ol015931+

  日期：2001.6.1

  [GRAPHICS]Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal chelating SAM. It has also been demonstrated that polymerized SAMs are much more stable than non polymerized counterparts. We report herein, the synthesis of several polymerizable, metal-chelating thiols capable of complexing luminescent lanthanide ions.