2'-deoxy-cytidine | 951-77-9

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 抗病毒类药
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-deoxy-cytidine
• 英文别名: Deoxycytidin；4-amino-1-[(4S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• CAS: 951-77-9；4251-19-8；4449-40-5；7060-91-5；40093-94-5；41545-93-1；41545-94-2；64727-75-9；109430-56-0
• 化学式: C₉H₁₃N₃O₄
• 分子量: 227.22
• InChiKey: CKTSBUTUHBMZGZ-BHZOKHGKSA-N

物化性质

• 沸点：
  497.6±55.0 °C(Predicted)
• 密度：
  1.73±0.1 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：250 mg/mL（1100.26 mM）

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29349990
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  HA3800000
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

制备方法与用途

生物活性

Torcitabine（2′-脱氧-L-胞苷）是一种抗病毒药物，可用于慢性乙型肝炎病毒感染的研究。

体外研究

Torcitabine (2'-Deoxy-L-cytidine) 在抑制第一链和第二链DNA合成方面表现出更强的抑制作用。

文献信息

• ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF
  申请人：Lakewood Amedex, Inc.

  公开号：US20210139522A1

  公开（公告）日：2021-05-13

  Antimicrobial compounds and compositions of Formulas (I) to (III) and methods of use are disclosed. Another aspect of the present disclosure provides a pharmaceutical composition comprising a compound according to Formula (I) to (III), or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, excipients, or diluents. Another aspect of the present disclosure provides a method of treating a bacterial infection in a patient in need thereof, the method of comprising administering an effective amount of a compound according to Formula (I) to (III), or a pharmaceutically acceptable salt thereof, to the patient.
• [EN] THERAPEUTIC SUBSTANCES THAT MODULATE GENOME METHYLATION<br/>[FR] SUBSTANCES THÉRAPEUTIQUES QUI MODULENT LA MÉTHYLATION DU GÉNOME
  申请人：RETROTOPE INC

  公开号：WO2009114814A2

  公开（公告）日：2009-09-17

  Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics.