1-(4-dimethylaminophenyl)imidazo [4,5,1-kl]phenoxazine-4-sulfonamide | 1428264-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(4-dimethylaminophenyl)imidazo [4,5,1-kl]phenoxazine-4-sulfonamide
• 英文别名: 15-[4-(Dimethylamino)phenyl]-8-oxa-1,14-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-2,4,6,9,11,13(16),14-heptaene-11-sulfonamide；15-[4-(dimethylamino)phenyl]-8-oxa-1,14-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-2,4,6,9,11,13(16),14-heptaene-11-sulfonamide
• CAS: 1428264-23-6
• 化学式: C₂₁H₁₈N₄O₃S
• 分子量: 406.465
• InChiKey: HXGIDMBNKMNJCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  98.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-nitro-10H-phenoxazine-3-sulfonylchloride 在 氨 、 一水合肼 作用下， 以 四氢呋喃 、 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 49.0h， 生成 1-(4-dimethylaminophenyl)imidazo [4,5,1-kl]phenoxazine-4-sulfonamide
  参考文献：
  名称：

  Novel imidazophenoxazine-4-sulfonamides: Their synthesis and evaluation as potential inhibitors of PDE4

  摘要：

  A number of novel imidazophenoxazine-4-sulfonamides have been designed as potential inhibitors of PDE4. All these compounds were readily prepared via an elegant multi-step method involving the initial construction of 1-nitro-10H-phenoxazine ring and then fused imidazole ring as key steps. Some of these compounds showed promising PDE4B and D inhibition when tested in vitro and good interactions with these proteins in silico. Three of these compounds showed dose dependent inhibition of PDE4B with IC50 value of 3.31 +/- 0.62, 1.23 +/- 0.18 and 0.53 +/- 0.18 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.01.023

文献信息

• Novel imidazophenoxazine-4-sulfonamides: Their synthesis and evaluation as potential inhibitors of PDE4
  作者：Seelam Venkata Reddy、Gangula Mohan Rao、Baru Vijaya Kumar、Chandana L.T. Meda、Girdhar Singh Deora、K. Shiva Kumar、Kishore V.L. Parsa、Manojit Pal

  DOI：10.1016/j.bmc.2013.01.023

  日期：2013.4

  A number of novel imidazophenoxazine-4-sulfonamides have been designed as potential inhibitors of PDE4. All these compounds were readily prepared via an elegant multi-step method involving the initial construction of 1-nitro-10H-phenoxazine ring and then fused imidazole ring as key steps. Some of these compounds showed promising PDE4B and D inhibition when tested in vitro and good interactions with these proteins in silico. Three of these compounds showed dose dependent inhibition of PDE4B with IC50 value of 3.31 +/- 0.62, 1.23 +/- 0.18 and 0.53 +/- 0.18 mu M. (C) 2013 Elsevier Ltd. All rights reserved.