2,2'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl))bis(oxy)diphenol | 68822-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl))bis(oxy)diphenol
• 英文别名: 1,11-bis(2-hydroxyphenoxy)-3,6,9-trioxaundecane；2-[2-(2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}ethoxy)ethoxy]phenol；2-[2-[2-[2-[2-(2-hydroxyphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]phenol
• CAS: 68822-98-0
• 化学式: C₂₀H₂₆O₇
• mdl: MFCD00068543
• 分子量: 378.422
• InChiKey: VFGLBBOQPBEAPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,2'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl))bis(oxy)diphenol 在 吡啶 作用下， 以 苯 为溶剂， 生成 (41r,42r,43r,44r)-42,44-diphenyl-2,6,8,11,14,17,20-heptaoxa-1,7(1,2)-dibenzena-4(1,3)-cyclobutanacycloicosaphane-3,5-dione
  参考文献：
  名称：

  The formation of arvltetralin derivatives in the photolysis of two trans-cinnamoyl moieties at both ends of a polyethylene glycol chain in the presence of lithium perchlorate

  摘要：

  报告中介绍了从含有一对反式肉桂酰基的 podand 体系制备芳基四氢萘衍生物 2a、b 的直接光化学路线。

  DOI：

  10.1039/c39910000375
• 作为产物：
  描述：

  双[2-(2-氯化乙氧基)乙基]醚 在 sodium hydroxide 、 palladium on activated charcoal 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 9.5h， 生成 2,2'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl))bis(oxy)diphenol
  参考文献：
  名称：

  Weber, Edwin, Liebigs Annalen der Chemie, 1983, # 5, p. 770 - 801

  摘要：

  DOI：

文献信息

• Highly Efficient Synthesis of Tetra Benzo Spiro bis-Crown Ether
  作者：Fatemeh Moradgholi、Hooshang Vahedi、Jalil Lari

  DOI：10.2174/1570178612666150108001219

  日期：2015.2.13

  Novel spiro bis-crown ethers derivatives with four benzo units connected via one carbon bridges have been prepared. These compounds represent well preorganized cavities with interesting complexation abilities towards cations. These macrocyclic were prepared by a four-step via template method by utilizing simple precursors catechol, oliethylen glycol and penta erythritol tetra bromide in good yield

  制备了具有通过一个碳桥连接的四个苯并单元的新型螺双冠醚衍生物。这些化合物代表了预组织良好的空腔，对阳离子具有有趣的络合能力。这些大环化合物通过模板步骤通过四步制备，利用简单的前体邻苯二酚，低聚乙二醇和季戊四醇四溴化物以高收率制备。另外，碳酸铯可以用作这些反应的优良碱。
• Synthesis of novel crownophanes containing two phenolic moieties via a tandem claisen rearrangement
  作者：Kazuhisa Hiratani、Hirotaka Uzawa、Kazuyuki Kasuga、Hide Kambayashi

  DOI：10.1016/s0040-4039(97)10403-8

  日期：1997.12

  A series of crownophanes containing two phenolic moieties within a macrocyclic ring have been successfully synthesized by a one-step thermal reaction from the corresponding macrocyclic polyethers by using a “Tandem Claisen Rearrangement”.

  通过使用“串联克莱森重排”，通过相应的大环聚醚的一步热反应，已经成功地合成了在大环环内包含一系列酚部分的一系列冠环烷。
• Colquhoun, Howard M.; Goodings, Eric P.; Maud, John M., Journal of the Chemical Society. Perkin transactions II, 1985, p. 607 - 624
  作者：Colquhoun, Howard M.、Goodings, Eric P.、Maud, John M.、Stoddart, J. Fraser、Wolstenholme, John B.、Williams, David J.

  DOI：——

  日期：——
• A New Approach to the Synthesis of Phenol-Containing Macroheterocycles
  作者：Andrei V. Bordunov、Nikolai G. Lukyanenko、Victor N. Pastushok、Krzysztof E. Krakowiak、Jerald S. Bradshaw、N. Kent Dalley、Xiaolan Kou

  DOI：10.1021/jo00120a040

  日期：1995.7

  A one-step method for the synthesis of new phenol-containing cryptands and cryptohemispherands by treating N,N'-bis(methoxymethyl)diazacrowns with the appropriate bis- and trisphenols is reported. This method, based on a special Mannich reaction, gives cyclized products without-the need for protecting groups and high dilution conditions. Unusually high yields of cryptohemisherands were realized using a relatively high concentration of the starting materials (50 mmol/L) and in the absence of metal cations as template agents in the reaction mixture. These excellent yields can be explained by intramolecular hydrogen bonding which prevents polycondensation. This new method also allowed preparation of new phenol-containing cylindrical tricyclic ligands by first forming bisphenol-substituted diaza-18-crown-6 at 80 degrees C followed by its reaction with a second bis(methoxymethyl)-substituted diaza-18-crown-6 at 144 degrees C. Crystal structures of two cryptohemispherands are reported herein. A shorter internal distance between N and O atoms in 27 as compared to 6 (R = NO2, n = m = 2) indicates intramolecular hydrogen bonding in phenol-containing macrocycle 27.
• Synthesis of highly lipophilic crown ether carboxylic acids
  作者：Richard A. Bartsch、Yung Liu、Sang Ihn Kang、Byungki Son、Gwi Suk Heo、Paul G. Hipes、Lyndra J. Bills

  DOI：10.1021/jo00173a016

  日期：1983.12