4-oxo-2-phenyl-4-p-tolyl-butyric acid | 35947-34-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-oxo-2-phenyl-4-p-tolyl-butyric acid
• 英文别名: 4-Oxo-2-phenyl-4-p-tolyl-buttersaeure；α-Phenyl-β-p-toluoylpropionsaeure；2-Phenyl-3-(p-toluoyl)-propionsaeure；4-(4-Methylphenyl)-4-oxo-2-phenylbutanoic acid；4-(4-methylphenyl)-4-oxo-2-phenylbutanoic acid
• CAS: 35947-34-3
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: NMUJEJTZQBYUBW-UHFFFAOYSA-N

物化性质

• 熔点：
  150 °C
• 沸点：
  470.8±40.0 °C(predicted)
• 密度：
  1.185±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4-oxo-2-phenyl-4-p-tolyl-butyric acid
  参考文献：
  名称：

  Allen; Normington; Wilson, Canadian Journal of Research, 1934, vol. 11, p. 386

  摘要：

  DOI：

文献信息

• Single-Step Synthesis of γ-Ketoacids through a Photoredox-Catalyzed Dual Decarboxylative Coupling of α-Oxo Acids and Maleic Anhydrides
  作者：Alex M. Davies、Shrikant S. Londhe、Emma R. Smith、Jon A. Tunge

  DOI：10.1021/acs.orglett.3c03258

  日期：2023.12.8

  A photocatalytic methodology for the single step synthesis of γ-ketoacids from α-ketoacids has been developed. This method employs maleic anhydrides as traceless synthetic equivalents of acrylic acids, achieving a selective cross-coupling via a dual decarboxylative strategy, where molecular CO2 is released as the only waste byproduct. The method has also been expanded to incorporate a highly regioselective

  开发了一种从 α-酮酸一步合成 γ-酮酸的光催化方法。该方法采用马来酸酐作为丙烯酸的无痕合成等价物，通过双重脱羧策略实现选择性交叉偶联，其中分子CO 2作为唯一的废物副产物被释放。该方法还得到了扩展，可将高度区域选择性的三组分与各种醇偶联，以获得功能化的 γ-酮酯。
• Electrophilic 1,4-Addition of Carbon Dioxide and Aldehydes to Enones
  作者：Shintaro Okumura、Kaoru Torii、Yasuhiro Uozumi

  DOI：10.1021/acs.orglett.3c01675

  日期：2023.7.21

  An umpoled electrophilic 1,4-addition to enones was achieved under photocatalytic conditions. Various enones reacted with CO2 in the presence of an iridium photocatalyst and a benzimidazoline reductant under blue-light irradiation to give the corresponding γ-keto carboxylic acids. Aldehydes also coupled with enones under similar photocatalytic conditions to afford γ-keto alcohols (homoaldols) that

  在光催化条件下实现了烯酮的未极化亲电 1,4-加成。各种烯酮在铱光催化剂和苯并咪唑啉还原剂存在下在蓝光照射下与CO 2反应生成相应的γ-酮基羧酸。醛还在类似的光催化条件下与烯酮偶联，得到γ-酮醇（高醛醇），通过共沸后处理将其转化为二氢呋喃和四氢呋喃。D 2 O 在 β 位的区域选择性氘掺入表明 1,4-加成是通过高烯醇阴离子发生的。
• Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict
  作者：A. Steib、G. Freys、C. Lehmann、C. Meyer、G. Mahoudeau

  DOI：10.1007/bf03020372

  日期：2001.12

  Purpose: To identify preoperative factor's associated with high blood losses during liver transplantation for chronic end-stage liver disease.Methods: Four hundred and ten consecutive patients were included in this retrospective study. Blood losses were calculated, based on transfusion requirements. The population was divided into two groups: the upper quartile was defined as the high blood loss (HBL) group and the lower three quartiles as the low blood loss group. Fourteen preoperative variables were collected, Qualitative variables consisted of the type of hepatopathy, Child-Pugh's classification, sex, the surgical team's experience, previous abdominal surgery and portal hypertension, Quantitative variables; were age, hemoglobin concentration Hb, platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen concentration, fibrin degradation products (FDP) and euglobulin lysis time. Univariate analysis and stepwise multivariate analysis were conducted.Results: Patients in the HBL group required 12 units of red blood cell or more to maintain a Hb greater than or equal to 100g.L-1. HBL was associated with severe liver disease, previous abdominal surgery, use of a venovenous bypass and little surgical experience in orthotopic liver transplantation (OLT). In the HBL group several hemostatic parameters were more disturbed before surgery. The multivariate analysis disclosed three independent variables associated with HBL: Hb and FDP concentrations and previous upper abdominal surgery. When combined, these resulted in a high specificity (98%) but low sensitivity to predict blood loss.Conclusion: Despite our efforts we were unable to identify predictive risk factors of bleeding during OLT even in a homogeneous population, Centres; should evaluate their practice individually in an attempt to identify patients at high risk of being trans-fused.
• Wali et al., Proceedings - Indian Academy of Sciences, Section A, 1941, # 14, p. 139,143
  作者：Wali et al.

  DOI：——

  日期：——
• Desai; Wali, Proceedings - Indian Academy of Sciences, Section A, 1937, vol. <A> 6, p. 135,142
  作者：Desai、Wali

  DOI：——

  日期：——