4-ethyl-N-(4-methoxyphenyl)aniline | 108714-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-ethyl-N-(4-methoxyphenyl)aniline
• CAS: 108714-37-0
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: KXTZFRVFLFWIHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯磺酰胺,N-(4-乙基苯基)-4-甲基- 在 bismuth(lll) trifluoromethanesulfonate 、 碘苯二乙酸 、 三氟乙酸 、 锌 作用下， 以 甲醇 为溶剂， 反应 0.08h， 生成 4-ethyl-N-(4-methoxyphenyl)aniline
  参考文献：
  名称：

  通过氧化脱芳香化反应-氨基交换-还原芳香化反应由两个芳香胺一锅法合成二芳基胺

  摘要：

  已经开发了仅使用芳族胺作为起始原料的二芳基胺的一锅合成策略。该方法涉及PhI（OAc）2诱导的N-磺酰基保护的对位取代苯胺的氧化脱芳香化作用，Bi（OTf）3催化的N-磺酰基环己二亚胺和芳香胺之间的亚氨基交换反应，以及CF 3 COOH / Zn介导的所得N-芳基环己二亚胺的还原芳构化。

  DOI：

  10.1021/ol4007162

文献信息

• Enhancing reductive C–N coupling of nitrocompounds through interfacial engineering of MoO₂ in thin carbon layers
  作者：Mengting Liu、Xuexue Dong、Xiu Zhong、Zhenxiao Wang、Juanjuan Gong、Heng Song、Chao Yu、Aihua Yuan、Fu Yang、Edison Huixiang Ang

  DOI：10.1039/d3cc03757f

  日期：——

  In this study, we developed an approach by coating silica nanospheres with polydopamine and metal precursor, followed by carbonization to create interfacial engineered MoO2. The presence of numerous crystal interfaces and metal–carbon interactions resulted in a remarkable enhancement of C–N coupling activity and stability of catalyst compared to one obtained by air calcination.

  在这项研究中，我们开发了一种方法，用聚多巴胺和金属前体涂覆二氧化硅纳米球，然后碳化以产生界面工程 MoO 2。与空气煅烧获得的催化剂相比，大量晶体界面和金属-碳相互作用的存在导致催化剂的C-N偶联活性和稳定性显着增强。
• Photoinduced Reduction of Nitroarenes and Tandem C–N Cross-Coupling with Haloarenes
  作者：Haoshi Bao、Leifeng Wang

  DOI：10.1021/acs.orglett.3c03656

  日期：2023.12.15

  photocatalytic C–N cross-coupling of nitroarenes with haloarenes has been developed using simple and cheap Ni(acac)2 as a cocatalyst. The reaction is confirmed as a stepwise process: (1) metal free photoinduced reduction of nitroarenes into aniline derivatives and (2) photo- and Ni-catalyzed C–N cross-coupling of anilines with haloarenes. The reaction conditions are simple and mild, giving high-value diarylamines

  使用简单且廉价的 Ni(acac) 2作为助催化剂，开发了硝基芳烃与卤代芳烃的高效光催化 C-N 交叉偶联。该反应被证实是一个逐步过程：（1）无金属光诱导硝基芳烃还原成苯胺衍生物，（2）苯胺与卤代芳烃的光催化和镍催化C-N交叉偶联。反应条件简单温和，可得到高价值的二芳基胺，具有良好的收率和良好的官能团耐受性。
• QUINAZOLINE DERIVATIVES WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE
  申请人：Novartis AG

  公开号：EP1401451B1

  公开（公告）日：2009-11-11
• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Ventana Medical Systems, Inc.

  公开号：US20160139143A1

  公开（公告）日：2016-05-19

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
• US7557110B2
  申请人：——

  公开号：US7557110B2

  公开（公告）日：2009-07-07