Ethyl 5-phenylhept-6-enoate | 131379-29-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 5-phenylhept-6-enoate
• CAS: 131379-29-8
• 化学式: C₁₅H₂₀O₂
• 分子量: 232.323
• InChiKey: IEKNBKFXPQICID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  β-(Iodzinkio)propionsaeureethylester 、 Cinnamyl bromide 在 copper(l) cyanide 作用下， 以 四氢呋喃 、 N,N-二甲基乙酰胺 为溶剂， 以75%的产率得到Ethyl 5-phenylhept-6-enoate
  参考文献：
  名称：

  Photoinduced Synthesis of Diorganozinc and Organozinc Iodide Reagents

  摘要：

  DOI：

  10.1021/ja980318f

文献信息

• Iridium-Catalyzed Enantioselective Allylic Alkylation with Functionalized Organozinc Bromides
  作者：James Y. Hamilton、David Sarlah、Erick M. Carreira

  DOI：10.1002/anie.201501851

  日期：2015.6.22

  Iridium‐catalyzed enantioselective allylic alkylation of branched racemic carbonates with functionalized alkylzinc bromide reagents is described. Enabled by a chiral Ir/(P,olefin) complex, the method described allows allylic substitution with various primary and secondary alkyl nucleophiles with excellent regio‐ and enantioselectivities. The developed reaction was showcased in a concise, asymmetric

  描述了用功能化烷基溴化锌试剂进行的铱催化支链外消旋碳酸酯的对映选择性烯丙基烷基化反应。通过手性Ir /（P，烯烃）络合物的实现，所描述的方法可以用具有优异的区域和对映选择性的各种伯和仲烷基亲核试剂进行烯丙基取代。简明的，不对称合成（-）preclamol展示了已开发的反应。
• The direct formation of functionalized alkyl(aryl)zinc halides by oxidative addition of highly reactive zinc with organic halides and their reactions with acid chlorides, .alpha.,.beta.-unsaturated ketones, and allylic, aryl, and vinyl halides
  作者：Lishan Zhu、Richard M. Wehmeyer、Reuben D. Rieke

  DOI：10.1021/jo00004a021

  日期：1991.2

  Highly reactive zinc, prepared by the lithium naphthalenide reduction of ZnCl2, readily undergoes oxidative addition to alkyl, aryl, and vinyl halides under mild conditions to generate the corresponding organozinc compounds in excellent yields. Significantly, the reaction will tolerate a spectrum of functional groups on the organic halides. Accordingly, this approach can now be used to prepare a wide variety of highly functionalized organozinc compounds. In the presence of Cu(I) salts, the organozinc compounds cross-couple with acid chlorides, conjugatively add to alpha,beta-unsaturated ketones, and regioselectively undergo S(N)2' substitution reactions with allylic halides. They also cross-couple with aryl or vinyl halides with Pd(0) catalysts.
• US5358546A
  申请人：——

  公开号：US5358546A

  公开（公告）日：1994-10-25
• US5756653A
  申请人：——

  公开号：US5756653A

  公开（公告）日：1998-05-26
• US5964919A
  申请人：——

  公开号：US5964919A

  公开（公告）日：1999-10-12