N2,N6-dimethoxy-N2,N6-dimethylpyridine-2,6-dicarboxamide | 189696-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N2,N6-dimethoxy-N2,N6-dimethylpyridine-2,6-dicarboxamide
• 英文别名: 2-N,6-N-dimethoxy-2-N,6-N-dimethylpyridine-2,6-dicarboxamide
• CAS: 189696-56-8
• 化学式: C₁₁H₁₅N₃O₄
• 分子量: 253.258
• InChiKey: LFFFWNRWRQTLSC-UHFFFAOYSA-N

物化性质

• 沸点：
  495.2±30.0 °C(Predicted)
• 密度：
  1.229±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N2,N6-dimethoxy-N2,N6-dimethylpyridine-2,6-dicarboxamide 、 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one 在 lithium diisopropyl amide 、 diethylzinc 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.67h， 生成
  参考文献：
  名称：

  Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers

  摘要：

  Thermolysis of 6,6'-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.100
• 作为产物：
  描述：

  2,6-氯甲酰吡啶 、 二甲羟胺盐酸盐 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以77%的产率得到N2,N6-dimethoxy-N2,N6-dimethylpyridine-2,6-dicarboxamide
  参考文献：
  名称：

  Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers

  摘要：

  Thermolysis of 6,6'-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.100

文献信息

• Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20130102600A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及一种具有通式I的化合物，可选地以药物可接受的盐、溶剂化物、多晶型、前药、互变异构体、外消旋体、对映体、非对映体或其混合物的形式，该化合物在治疗、改善或预防病毒性疾病方面有用。此外，还公开了特定的组合疗法。
• Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20130102601A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及具有通式II的化合物，可选地以药学上可接受的盐、溶剂合物、多型体、前药、互变异构体、消旋体、对映体或二对映体或其混合物的形式存在，用于治疗、改善或预防病毒性疾病。此外，还披露了特定的联合疗法。
• [EN] ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH NEW CHIRAL LIGANDS<br/>[FR] SYNTHESE ASYMETRIQUE CATALYSEE PAR DES COMPLEXES DE METAUX DE TRANSITION ASSOCIES A DE NOUVEAUX LIGANDS CHIRAUX
  申请人：THE PENN STATE RESEARCH FOUNDATION

  公开号：WO1997013763A1

  公开（公告）日：1997-04-17

  (EN) A chiral ligand having structure (I) wherein AR is any aromatic and/or ring structure, and R is selected from the group consisting of aryl, oxygenated aryl, alkyl, oxygenated alkyl, AR, oxygenated AR and combinations thereof.(FR) L'invention porte sur un ligand chiral représenté par la formule (I), où AR est une structure aromatique et/ou cyclique, et R est choisi dans le groupe constitué d'aryle, d'aryle oxygéné, d'alkyle, d'alkyle oxygéné, d'AR, d'AR oxygéné, et de leurs combinaisons.

  一种具有结构(I)的立体配位剂，其中AR是任何芳香烃基或环结构，而R选择自以下基团的组合：芳香基，氧代芳香基，烷基，氧代烷基，AR，氧代AR及其组合。
• EP0871621A4
  申请人：——

  公开号：EP0871621A4

  公开（公告）日：1999-10-13
• ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH NEW CHIRAL LIGANDS
  申请人：THE PENN STATE RESEARCH FOUNDATION

  公开号：EP0871621A1

  公开（公告）日：1998-10-21