1-benzyl-4-(9H-carbazol-9-ylmethyl)piperidin-4-ol | 1357011-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-benzyl-4-(9H-carbazol-9-ylmethyl)piperidin-4-ol
• 英文别名: 1-Benzyl-4-(9h-carbazol-9-ylmethyl)piperidin-4-ol；1-benzyl-4-(carbazol-9-ylmethyl)piperidin-4-ol
• CAS: 1357011-82-5
• 化学式: C₂₅H₂₆N₂O
• 分子量: 370.494
• InChiKey: SHHXKPZHUMWNIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  28.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-4-(9H-carbazol-9-ylmethyl)piperidin-4-ol 在 5%-palladium/activated carbon 、 氢气 、 三乙酰氧基硼氢化钠 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 N-[3-[4-(9H-carbazol-9-ylmethyl)-4-hydroxypiperidin-1-yl]-1-phenylpropyl]-4-fluorobenzamide
  参考文献：
  名称：

  Synthesis and biological evaluation of novel piperidin-4-ol derivatives

  摘要：

  A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by H-1 NMR, C-13 NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated.

  DOI：

  10.1007/s00706-011-0645-9
• 作为产物：
  描述：

  N-苄基哌啶酮 在 四丁基溴化铵 、 sodium hydroxide 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 1-benzyl-4-(9H-carbazol-9-ylmethyl)piperidin-4-ol
  参考文献：
  名称：

  Synthesis and biological evaluation of novel piperidin-4-ol derivatives

  摘要：

  A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by H-1 NMR, C-13 NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated.

  DOI：

  10.1007/s00706-011-0645-9

文献信息

• Synthesis and biological evaluation of novel piperidin-4-ol derivatives
  作者：Zhiyong Weng、Wei Wei、Xiaowu Dong、Yongzhou Hu、Shufang Huang、Tao Liu、Xin Xie

  DOI：10.1007/s00706-011-0645-9

  日期：2012.2

  A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by H-1 NMR, C-13 NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated.