5-amino-2-propoxybenzoic acid | 13851-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-2-propoxybenzoic acid
• 英文别名: 1-(4-Amino-2-carboxyphenoxy)-propan；Benzoic acid, 5-amino-2-propoxy-
• CAS: 13851-59-7
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: WLXTWCDTEYNQMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻丙氧基苯甲酸 在 硝酸 、 二氧化氮 作用下， 以 溶剂黄146 为溶剂， 生成 5-amino-2-propoxybenzoic acid
  参考文献：
  名称：

  血吸虫病的化学疗法。第八部分 2-羧基和2-氨基甲酰基-4-氨基苯基醚

  摘要：

  通过引入羧基-，氨基甲酰基-，烷基磺酰基-和一些其他核取代基进行结构活性研究，继续进行了一系列血吸虫的对氨基苯醚的合成工作。

  DOI：

  10.1039/j39660002196

文献信息

• Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field
  申请人：Naccari Giancarlo

  公开号：US20090118357A1

  公开（公告）日：2009-05-07

  Therefore the present invention relates specifically to the compounds of general formula (I), in which R 1 and R 2 , which may be identical or different, are selected from the group comprising H, —C n H 2n-1 , a linear or branched alkyl group having from 1 to 6 carbon atoms, or together form an aromatic or aliphatic ring with 5 or 6 atoms; R 3 is selected from —CO—CH 3 , —NHOH, —OH, —OR 6 in which R 6 is a linear or branched alkyl group having from 1 to 6 carbon atoms; R 4 is selected from H, a linear or branched alkyl group having from 1 to 6 carbon atoms, phenyl, benzyl, —CF 3 or —CF 2 CF 3 , vinyl or allyl; R 5 , R 7 , R 8 are hydrogen atoms; or R 3 and R 4 , R 4 and R 5 , or R 7 and R 8 together form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O, and use thereof in the medical field.

  因此，本发明特别涉及具有通用公式（I）的化合物，其中R1和R2，可以相同或不同，选自包括H，—CnH2n-1，具有1到6个碳原子的直链或支链烷基，或者共同形成一个含有5或6个原子的芳香族或脂肪族环；R3选自—CO—CH3，—NHOH，—OH，—OR6，其中R6是一个具有1到6个碳原子的直链或支链烷基；R4选自H，具有1到6个碳原子的直链或支链烷基，苯基，苄基，—CF3或—CF2CF3，乙烯基或烯丙基；R5，R7，R8是氢原子；或者R3和R4，R4和R5，或R7和R8共同形成一个环，与苯环，芳香族或脂肪族环融合，含有5或6个原子，并包括1到2个独立选自N，O的杂原子，及其在医疗领域的应用。
• Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0442204A3

  公开（公告）日：1992-02-19

  Compounds of the formula (1): and pharmaceutically acceptable salts are described wherein R¹ is C₁₋₆alkyl, C₂₋₆alkenyl, C₃₋₅cycloalkyl C₁₋₆alkyl, or C₁₋₆alkyl substituted by 1 to 6 fluoro groups; R² is C₁₋₆alkylthio, C₁₋₆alkylsulphonyl, C₁₋₆alkoxy, hydroxy, hydrogen, hydrazino, C₁₋₆alkyl, phenyl, ―NHCOR³ wherein R³ is hydrogen or C₁₋₆alkyl, or ―NR⁴R⁵, wherein R⁴ and R⁵ together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, hexahydroazepino, morpholino or piperazino ring, or R⁴ and R⁵ are independently hydrogen, C₃₋₅cycloalkyl or C₁₋₆alkyl which is optionally substituted by ―CF₃, phenyl, ―S(O)nC₁₋₆alkyl wherein n is 0, 1 or 2, ―OR⁶, ―CO₂R⁷ or ―NR⁸R⁹ wherein R⁶ to R⁹ are independently hydrogen or C₁₋₆alkyl, provided that the carbon atom adjacent to the nitrogen atom is not substituted by said ―S(O)nC₁₋₆alkyl, ―OR⁶ or ―NR⁸R⁹ groups; R is halo, C₁₋₄alkyl, C₁₋₄ alkoxy, cyano, ―CONR¹⁰R¹¹, CO₂R¹², C₁₋₄alkylS(O)n, ―NO₂, ―NH₂, ―NHCOR¹³ or SO₂NR¹⁴R¹⁵ wherein n is 0, 1 or 2 and R¹⁰ to R¹⁵ are independently hydrogen or C₁₋₄alkyl; and is a ring of sub-formula (a) or (b) : These compounds have bronchodilatator, anti-allergic, and vasodilator activities. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of compounds of the formula (1) are described.

  描述了公式（1）的化合物和药用盐，其中 R¹为C₁₋₆烷基，C₂₋₆烯基，C₃₋₅环烷基，C₁₋₆烷基，或者由1到6个氟原子取代的C₁₋₆烷基；R²为C₁₋₆硫代烷基，C₁₋₆磺酰基，C₁₋₆烷氧基，羟基，氢，叠氮基，C₁₋₆烷基，苯基，―NHCOR³，其中R³为氢或C₁₋₆烷基，或者―NR⁴R⁵，其中R⁴和R⁵与它们连接的氮原子一起形成吡咯烷基，哌啶基，六氢吖啶基，吗啉基或哌嗪基，或者R⁴和R⁵独立地为氢，C₃₋₅环烷基或C₁₋₆烷基，可选地被―CF₃，苯基，―S(O)nC₁₋₆烷基取代，其中n为0，1或2，―OR⁶，―CO₂R⁷或―NR⁸R⁹，其中R⁶到R⁹独立地为氢或C₁₋₆烷基，但是要求氮原子相邻的碳原子未被上述的―S(O)nC₁₋₆烷基，―OR⁶或―NR⁸R⁹取代；R为卤素，C₁₋₄烷基，C₁₋₄烷氧基，氰基，―CONR¹⁰R¹¹，CO₂R¹²，C₁₋₄烷基S(O)n，―NO₂，―NH₂，―NHCOR¹³或SO₂NR¹⁴R¹⁵，其中n为0，1或2，R¹⁰到R¹⁵独立地为氢或C₁₋₄烷基；并且为子公式（a）或（b）的环：这些化合物具有支气管扩张剂、抗过敏和血管扩张剂活性。描述了药物组合物以及使用方法。描述了制备公式（1）化合物的方法。
• Enzymatic method for textile dyeing
  申请人：Novozymes A/S

  公开号：US20010037532A1

  公开（公告）日：2001-11-08

  The present invention relates to methods of dyeing a material which involve contacting the material with a dyeing system which comprises: (a) a mixture of (i) an aromatic diamine and (ii) one or more of a naphthol and an aminonaphthalene and (b) an oxidation system comprising (i) a hydrogen peroxide source and an enzyme exhibiting peroxidase activity or (ii) an enzyme exibiting oxidase activity on one or more of the compounds of mixture (a). The material may be a fabric, yarn, fiber, garment or film made of fur, hide, leather, silk or wool, or made of cationic polysaccharide, cotton, diacetate, flax, linen, lyocel, polyacrylic, synthetic polyamide, polyester, ramie, rayon, triacetate, or viscose.

  本发明涉及一种染色材料的方法，其中涉及将材料与染色系统接触，该染色系统包括：（a）芳香族二胺和萘酚和/或氨基萘之一或多种的混合物；以及（b）氧化系统，其中包括（i）过氧化氢源和表现出过氧化酶活性的酶或（ii）在混合物（a）中的一种或多种化合物上表现出氧化酶活性的酶。该材料可以是毛皮、兽皮、皮革、丝绸或羊毛制成的织物、纱线、纤维、服装或薄膜，或是阳离子多糖、棉、醋酸二乙酯、亚麻、亚麻布、莱赛尔、聚丙烯酸、合成聚酰胺、聚酯、苎麻、人造丝或粘胶制成的织物、纱线、纤维、服装或薄膜。
• DYEING AGENT AND USE FOR SAME
  申请人：Amano Enzyme Inc.

  公开号：EP2708223A1

  公开（公告）日：2014-03-19

  The object is to provide a process for dyeing that can provide an excellent dyeing effect while utilizing an oxidase, and a dyeing agent for use in the process. Provided is a dyeing agent comprising a modified enzyme obtained by adding positive charge by a chemical modification with an amine to an enzyme selected from the group consisting of an enzyme specified as EC 1.10.3.1, an enzyme specified as EC 1.10.3.2, an enzyme specified as EC 1.3.3.5, an enzyme specified as EC 1.10.3.4, an enzyme specified as EC 1.10.3.3 and an enzyme specified as EC 1.14.18.1. A process for dyeing using the dyeing agent is also provided.

  本发明的目的是提供一种在利用氧化酶的同时能够提供出色染色效果的染色工艺，以及一种用于该工艺的染色剂。本发明提供了一种染色剂，该染色剂包含一种改性酶，该改性酶是通过对选自 EC 1.10.3.1 酶、EC 1.10.3.2 酶、EC 1.3.3.5 酶、EC 1.10.3.4 酶、EC 1.10.3.3 酶和 EC 1.14.18.1 酶组的酶进行胺化学改性而获得正电荷。还提供了一种使用染色剂进行染色的工艺。
• Dye composition for keratinous fiber
  申请人：Kao Corporation

  公开号：EP0345728B1

  公开（公告）日：1994-09-14