(4-((3-chloro-4-fluorophenyl)(methyl)amino)thieno[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone | 1355970-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (4-((3-chloro-4-fluorophenyl)(methyl)amino)thieno[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone
• 英文别名: [4-(3-chloro-4-fluoro-N-methylanilino)thieno[2,3-d]pyrimidin-6-yl]-(1H-indol-2-yl)methanone
• CAS: 1355970-23-8
• 化学式: C₂₂H₁₄ClFN₄OS
• 分子量: 436.897
• InChiKey: NTTSBRQVYORONV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (4-(3-chloro-4-fluorophenylamino)thieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone 在 水 、 sodium hydride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 mineral oil 为溶剂， 反应 1.58h， 生成 (4-((3-chloro-4-fluorophenyl)(methyl)amino)thieno[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone
  参考文献：
  名称：

  Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

  摘要：

  Several members of the quinazoline class of known tyrosine kinase inhibitors are approved anticancer agents, often showing selectivity for receptors of the HER/ErbB-family. Combining structural elements of this class with the bisindolylmethanone-structure led to a series of novel compounds. These compounds inhibited EGFR in the nanomolar range. Moreover, inhibition of EGFR autophosphorylation in intact A431 cells was shown, with IC50 values ranging form 0.3-1 mu M for compound 42, and 0.1-0.3 mu M for 45. In a panel of 42 human tumor cell lines the sensitivity profile of the novel compounds was shown to be similar to that of the quinazoline class of tyrosine kinase inhibitors lapatinib and erlotinib (Tarceva (R)). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.023

文献信息

• Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones
  作者：Thomas Beckers、Andreas Sellmer、Emerich Eichhorn、Herwig Pongratz、Christoph Schächtele、Frank Totzke、Gerhard Kelter、Rebekka Krumbach、Heinz-Herbert Fiebig、Frank-D. Böhmer、Siavosh Mahboobi

  DOI：10.1016/j.bmc.2011.11.023

  日期：2012.1

  Several members of the quinazoline class of known tyrosine kinase inhibitors are approved anticancer agents, often showing selectivity for receptors of the HER/ErbB-family. Combining structural elements of this class with the bisindolylmethanone-structure led to a series of novel compounds. These compounds inhibited EGFR in the nanomolar range. Moreover, inhibition of EGFR autophosphorylation in intact A431 cells was shown, with IC50 values ranging form 0.3-1 mu M for compound 42, and 0.1-0.3 mu M for 45. In a panel of 42 human tumor cell lines the sensitivity profile of the novel compounds was shown to be similar to that of the quinazoline class of tyrosine kinase inhibitors lapatinib and erlotinib (Tarceva (R)). (C) 2011 Elsevier Ltd. All rights reserved.