(2S)-2,6-diamino-N-[(5S)-5-[[(2S)-2,6-diaminohexanoyl]amino]-6-(dodecylamino)-6-oxohexyl]hexanamide | 1026229-42-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2,6-diamino-N-[(5S)-5-[[(2S)-2,6-diaminohexanoyl]amino]-6-(dodecylamino)-6-oxohexyl]hexanamide
• CAS: 1026229-42-4
• 化学式: C₃₀H₆₃N₇O₃
• 分子量: 569.875
• InChiKey: JWHBDVNDJOTUTJ-QKDODKLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  40
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  191
• 氢给体数：
  7
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,1,1-trifluoro-4-(4-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol 、 N,N'-双芴甲氧羰基-L-赖氨酸 在 N,N'-二异丙基碳二亚胺 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 反应 16.25h， 以47%的产率得到(2S)-2,6-diamino-N-[(5S)-5-[[(2S)-2,6-diaminohexanoyl]amino]-6-(dodecylamino)-6-oxohexyl]hexanamide
  参考文献：
  名称：

  Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers

  摘要：

  A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal 'tail groups' such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.127

文献信息

• Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers
  作者：Daniel K. Svenssen、Sahar Mirsharghi、Ulrik Boas

  DOI：10.1016/j.tetlet.2014.04.127

  日期：2014.7

  A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal 'tail groups' such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis. (C) 2014 Elsevier Ltd. All rights reserved.