6-Amino-2-(2-methylprop-2-enoylamino)hexanoic acid | 45159-28-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Amino-2-(2-methylprop-2-enoylamino)hexanoic acid
• CAS: 45159-28-2
• 化学式: C₁₀H₁₈N₂O₃
• 分子量: 214.265
• InChiKey: FQYPKQOQUNFBDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基丙烯酰氯 、 L-赖氨酸盐酸盐 在 potassium hydrogencarbonate 作用下， 以 水 、 丙酮 为溶剂， 反应 2.17h， 生成 6-Amino-2-(2-methylprop-2-enoylamino)hexanoic acid 、 C₁₀H₁₈N₂O₃
  参考文献：
  名称：

  JP5978059

  摘要：

  公开号：

文献信息

• THERMO-RESPONSIVE HYDROGEL COMPOSITIONS
  申请人：KANG-MIELER Jennifer J.

  公开号：US20120231072A1

  公开（公告）日：2012-09-13

  A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

  一种热响应性水凝胶，包括具有氨基酸侧链的生物相容性单体和/或聚合物。该水凝胶在生理温度下具有热响应性，可以包含、结合或封装治疗剂，如药物组合物、生物分子和/或纳米颗粒。该水凝胶在传递治疗剂方面很有用。该水凝胶处于第一物理化学状态以用于哺乳动物。该水凝胶在哺乳动物的生理温度下具有热响应性，并转变为比第一物理化学状态更固体的第二物理化学状态。在第二物理化学状态下，热响应性水凝胶释放治疗剂。
• AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20210388142A1

  公开（公告）日：2021-12-16

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R 1 , and R 2 are as described herein.

  提供了基于氨基酸的可聚合化合物及其在眼科设备中的应用。该基于氨基酸的可聚合化合物的化学式为I：其中R，R1和R2如本文所述。
• Optical determination of glucose utilizing boronic acid adducts
  申请人：Singaram Bakthan

  公开号：US20060083688A1

  公开（公告）日：2006-04-20

  The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

  本发明涉及一种改进的光学方法和光学传感器设备，用于在体内和/或体外的水性介质中确定多羟基取代有机分子的水平。检测范围在约400至800纳米之间。特别地，实施了一种感官设备在哺乳动物中以确定糖的水平。具体来说，染料与含有硼酸取代双阳离子化氮杂芳香化合物结合在一起，与糖如果糖或葡萄糖同时存在。香豆素类化合物是偏爱作为芳香性取代硼酸氮杂芳香化合物。该方法对于确定人体内的糖水平是有用的。
• OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS
  申请人：SINGARAM Bakthan

  公开号：US20120009126A1

  公开（公告）日：2012-01-12

  The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

  本发明涉及一种改进的光学方法和光学传感器装置，用于在体内和/或体外的水介质中确定多羟基取代有机分子的水平。检测范围在大约400到800纳米之间。特别地，实施了一种传感器装置在哺乳动物中，以确定糖的水平。具体地，将染料与含有硼酸取代的氮杂环芳香基双阳离子化合物结合，在存在糖，如果糖或葡萄糖的情况下。偏好使用紫罗兰作为芳香性共轭氮取代硼酸化合物。该方法对于确定人体内的糖水平非常有用。
• Skin lightening preparation comprising n-butyl resorcinol and a flavonoid
  申请人：Kuraray Co., Ltd.

  公开号：EP1543825A1

  公开（公告）日：2005-06-22

  The present invention relates to an external preparation for skin comprising a compound, such as centaureidin(5,7-dihydroxy-3,6-dimethoxy-2-(5-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one); 5,7-dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5-diethoxy-6,7-dimethoxy-2-(5-ethoxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; and 5,6-dihydroxy-3,7-dimethoxy-2-(5-hydroxy-2,4-dimethoxyphenyl)-4H-1-benzopyran-4-one; and/or salt thereof and 4-n-butyl resorcinol and/or a salt thereof. The present invention provides an external preparation for skin having a function as a substantial lightening cosmetic that exerts whitening action of inhibiting excessive melanin production and keeping natural-looking whiteness.

  本发明涉及一种皮肤外用制剂，其中包含一种化合物，例如仙人掌素（5,7-二羟基-3,6-二甲氧基-2-(5-羟基-4-甲氧基苯基)-4H-1-苯并吡喃-4-酮）； 5,7-dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5-二乙氧基-6,7-二甲氧基-2-(5-乙氧基-4-甲氧基苯基)-4H-1-苯并吡喃-4-酮；以及 5,6-二羟基-3,7-二甲氧基-2-(5-羟基-2,4-二甲氧基苯基)-4H-1-苯并吡喃-4-酮；和/或其盐和 4-正丁基间苯二酚和/或其盐。 本发明提供了一种皮肤外用制剂，它具有实质性美白化妆品的功能，可抑制黑色素的过度生成并保持自然美白。