1-(1-(3-bromophenyl)vinyl)-1H-indole | 1440537-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(1-(3-bromophenyl)vinyl)-1H-indole
• 英文别名: 1H-Indole, 1-[1-(3-bromophenyl)ethenyl]-；1-[1-(3-bromophenyl)ethenyl]indole
• CAS: 1440537-88-1
• 化学式: C₁₆H₁₂BrN
• 分子量: 298.182
• InChiKey: NMJMIPIQAQVLCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3'-溴苯乙酮 在 bis-triphenylphosphine-palladium(II) chloride 、 氧气 、 lithium tert-butoxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 1-(1-(3-bromophenyl)vinyl)-1H-indole
  参考文献：
  名称：

  Palladium-Catalyzed Oxidative Cross-Coupling of N-Tosylhydrazones with Indoles: Synthesis of N-Vinylindoles

  摘要：

  A general and efficient palladium-catalyzed oxidative cross-coupling reaction of N-tosylhydrazones with indoles providing N-vinylindoles has been developed. The reaction proceeds smoothly with various indoles and N-tosylhydrazones in a stereocontrolled manner, and a wide variety of N-vinylindoles were obtained up to 99% yields for 26 examples.

  DOI：

  10.1021/ol401217h

文献信息

• Palladium-Catalyzed Oxidative Cross-Coupling of <i>N-</i>Tosylhydrazones with Indoles: Synthesis of <i>N-</i>Vinylindoles
  作者：Xiaobao Zeng、Guolin Cheng、Jinhai Shen、Xiuling Cui

  DOI：10.1021/ol401217h

  日期：2013.6.21

  A general and efficient palladium-catalyzed oxidative cross-coupling reaction of N-tosylhydrazones with indoles providing N-vinylindoles has been developed. The reaction proceeds smoothly with various indoles and N-tosylhydrazones in a stereocontrolled manner, and a wide variety of N-vinylindoles were obtained up to 99% yields for 26 examples.