(R)-4-chloro-α-(1-methylethyl)benzenecaetyl chloride | 71697-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-4-chloro-α-(1-methylethyl)benzenecaetyl chloride
• 英文别名: (2R)-2-(4-chlorophenyl)-3-methylbutanoyl chloride
• CAS: 71697-10-4
• 化学式: C₁₁H₁₂Cl₂O
• 分子量: 231.122
• InChiKey: BWPYAVCZZUTOBY-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-4-chloro-α-(1-methylethyl)benzenecaetyl chloride 在 ammonium hydroxide 作用下， 以96.8 %的产率得到(R)-2-isopropyl-4'-chlorophenylacetamide
  参考文献：
  名称：

  一种新型折分剂的制备方法

  摘要：

  本发明涉及一种新型折分剂的制备方法，以R（‑）2‑对氯苯基‑3‑甲基丁酸为原料，经过酰氯化、酰胺化、霍夫曼降解反应制得R（+）2‑对氯苯基‑3‑甲基丁胺，每步收率均大于95%；R（+）2‑对氯苯基‑3‑甲基丁胺可同时用于（±）第一菊酸、（±）二氯菊酸的拆分，降低成本，减少劳动力强度，同时所用原料价廉易得、反应条件温和、反应操作简单，减少工作量、合成收率高、产品质量好等优点，具有很高的工业生产经济价值。

  公开号：

  CN115232014A
• 作为产物：
  描述：

  2-(4-氯苯基)-3-甲基丁酸 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 氯仿 为溶剂， 反应 1.0h， 生成 (R)-4-chloro-α-(1-methylethyl)benzenecaetyl chloride
  参考文献：
  名称：

  Development of an Immunoassay for the Pyrethroid Insecticide Esfenvalerate

  摘要：

  A competitive enzyme-linked immunosorbent assay was developed for the detection of the pyrethroid insecticide esfenvalerate. Two haptens containing amine or propanoic acid groups on the terminal aromatic ring of the fenvalerate molecule were synthesized and coupled to carrier proteins as immunogens. Five antisera were produced and screened against eight different coating antigens. The assay that had the least interference and was the most sensitive for esfenvalerate was optimized and characterized. The I-50 for esfenvalerate was 30 +/- 6.2 mu g/L, and the lower detection limit (LDL) was 3.0 +/- 1.8 mu g/L. The assay was very selective. Other pyrethroid analogues and esfenvalerate metabolites tested did not cross-react significantly in this assay. To increase the sensitivity of the overall method, a C-18 sorbent-based. solid-phase extraction (SPE) was used for water matrix. With this SPE step, the LDL of the overall method for esfenvalerate was 0.1 mu g/L in water samples.

  DOI：

  10.1021/jf981210m

文献信息

• HIGHLY EFFICIENT ASYMMETRIC SYNTHESIS OF (S)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL FROM GLYCEROL
  作者：Teruaki Mukaiyama、Yoo Tanabe、Makoto Shimizu

  DOI：10.1246/cl.1984.401

  日期：1984.3.5

  (S)-2,2-Dimethyl-1,3-dioxolane-4-methanol was prepared from glycerol in high yield with high optical purity by simple procedure. The procedure involves acylation of cyclic tin(IV) alkoxide with an optical active acid chloride in the crucial step.

  (S)-2,2-二甲基-1,3-二氧戊环-4-甲醇通过简单的方法以高收率和高光学纯度由甘油制备。该程序包括在关键步骤中用光学活性酰氯酰化环状锡 (IV) 醇盐。
• Preparation of cyanomethyl esters
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0172380A2

  公开（公告）日：1986-02-26

  Cyanomethyl esters are prepared by reacting a carboxylic acid halide with an alpha-hydroxynitrile in the presence of a minor amount of water a molar excess of a hydrogen halide acceptor and a catalytic amount of a tertiary-aminopyridine or N-methylimidazole.

  在少量水、摩尔过量的卤化氢受体和催化量的叔氨基吡啶或 N-甲基咪唑存在下，通过羧酸卤化物与 α-羟腈反应制备氰甲基酯。
• MUKAIYAMA, TERUAKI;TANABE, YOO;SHIMIZU, MAKOTO, CHEM. LETT., 1984, N 3, 401-404
  作者：MUKAIYAMA, TERUAKI、TANABE, YOO、SHIMIZU, MAKOTO

  DOI：——

  日期：——
• US4293504A
  申请人：——

  公开号：US4293504A

  公开（公告）日：1981-10-06
• US4526727A
  申请人：——

  公开号：US4526727A

  公开（公告）日：1985-07-02