5-ethyl-3-hydroxy-2,3-dihydrofuran-3,4-dicarboxylic acid diethyl ester | 1048023-93-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-ethyl-3-hydroxy-2,3-dihydrofuran-3,4-dicarboxylic acid diethyl ester
• 英文别名: diethyl 5-ethyl-3-hydroxy-2H-furan-3,4-dicarboxylate
• CAS: 1048023-93-3
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: FHPQCMVGQQVPTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-溴丙酮酸乙酯 、 丙酰乙酸乙酯 在 1-butyl-3-methylimidazolium hydroxide 作用下， 反应 2.0h， 以75%的产率得到5-ethyl-3-hydroxy-2,3-dihydrofuran-3,4-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Ionic liquid promoted interrupted Feist–Benary reaction with high diastereoselectivity

  摘要：

  A basic ionic liquid, 1-butyl-3-methylimidazolium hydroxide promotes the interrupted Feist-Eenary reaction at room temperature under organic solvent-ftee conditions to produce a variety of substituted hydFOxydihydrofurans. The hydroxydihydrofurans are converted to furans (Feist-Benary products) using the ionic liquid, 1-methyl-3-pentylimidazolium bromide at 70-75 degrees C. The reactions are very clean, high yielding and highly stereoselective. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.083

文献信息

• Ionic liquid promoted interrupted Feist–Benary reaction with high diastereoselectivity
  作者：Brindaban C. Ranu、Laksmikanta Adak、Subhash Banerjee

  DOI：10.1016/j.tetlet.2008.05.083

  日期：2008.7

  A basic ionic liquid, 1-butyl-3-methylimidazolium hydroxide promotes the interrupted Feist-Eenary reaction at room temperature under organic solvent-ftee conditions to produce a variety of substituted hydFOxydihydrofurans. The hydroxydihydrofurans are converted to furans (Feist-Benary products) using the ionic liquid, 1-methyl-3-pentylimidazolium bromide at 70-75 degrees C. The reactions are very clean, high yielding and highly stereoselective. (c) 2008 Elsevier Ltd. All rights reserved.