7-Methoxy-10H-<1>benzothieno<3,2-b>indol | 95372-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-Methoxy-10H-<1>benzothieno<3,2-b>indol
• 英文别名: 7-methoxy-10H-[1]benzothiolo[3,2-b]indole
• CAS: 95372-56-8
• 化学式: C₁₅H₁₁NOS
• 分子量: 253.324
• InChiKey: NMNRMZHYUNGWJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  53.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-Methoxy-10H-<1>benzothieno<3,2-b>indol 在 哌啶 、 苯 作用下， 生成 7-methoxy-10-piperidinoacetyl-10H-benzo[4,5]thieno[3,2-b]indole
  参考文献：
  名称：

  Thianaphtheno [3,2-b]indoles

  摘要：

  DOI：

  10.1021/ja01564a040
• 作为产物：
  描述：

  3-甲氧基苯硫酚 在 sodium hydroxide 、 三氯化铝 、 溶剂黄146 、 三氯化磷 作用下， 以 1,1,2,2-四氯乙烷 为溶剂， 反应 5.5h， 生成 7-Methoxy-10H-<1>benzothieno<3,2-b>indol
  参考文献：
  名称：

  Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators

  摘要：

  A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ER alpha and ER beta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.111

文献信息

• Buu-Hoi,N.P.; Saint-Ruf,G., Israel Journal of Chemistry, 1963, vol. 1, p. 369 - 373
  作者：Buu-Hoi,N.P.、Saint-Ruf,G.

  DOI：——

  日期：——
• ORGANIC THIN FILM TRANSISTOR, ORGANIC SEMICONDUCTOR THIN FILM, AND ORGANIC SEMICONDUCTOR MATERIAL
  申请人：FUJIFILM Corporation

  公开号：US20150340625A1

  公开（公告）日：2015-11-26

  An organic thin film transistor containing a compound represented by one of the following formulae in a semiconductor active layer has a high carrier mobility and a small change in the threshold voltage after repeated driving. X represents S or O, Z represents a substituent having a length of 3.7 Å or less, and at least one of R 1 to R 8 represents -L-R wherein L represents alkylene, etc., and R represents alkyl, etc.
• Thianaphtheno [3,2-b]indoles
  作者：L. H. Werner、D. C. Schroeder、S. Ricca

  DOI：10.1021/ja01564a040

  日期：1957.4
• Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators
  作者：Qinggang Ji、Jie Gao、Junbo Wang、Chunhao Yang、Xin Hui、Xueming Yan、Xihan Wu、Yuyuan Xie、Ming-Wei Wang

  DOI：10.1016/j.bmcl.2005.03.111

  日期：2005.6

  A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ER alpha and ER beta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice. (c) 2005 Elsevier Ltd. All rights reserved.