2-羟基-6-甲氧基苯甲酰胺 | 145297-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-6-甲氧基苯甲酰胺
• 英文名称: 2-hydroxy-6-methoxybenzamide
• 英文别名: 2-hydroxy-6-methoxy-benzamide
• CAS: 145297-98-9
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: OPRVYHZQPOWGKF-UHFFFAOYSA-N

物化性质

• 沸点：
  329.0±32.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-羟基-6-甲氧基苯甲酰胺 在 硝酸 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 24.5h， 生成 2-hydroxy-6-methoxy-3-nitrobenzamide
  参考文献：
  名称：

  Compounds for diagnosis, treatment and prevention of bone injury and metabolic disorders

  摘要：

  本发明涉及以下式的化合物或其药用可接受盐，用于预防和治疗退行性骨疾病以及促进骨愈合。

  公开号：

  US20050143366A1
• 作为产物：
  描述：

  2-羟基-6-甲氧基苯甲醛 在 盐酸羟胺 、 caesium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 250.0 ℃ 、20.0 MPa 条件下， 反应 0.08h， 以82%的产率得到2-羟基-6-甲氧基苯甲酰胺
  参考文献：
  名称：

  使用流动化学从醇或醛高温合成酰胺

  摘要：

  通过使用流动化学成功地实现了脂肪族和芳香族醇或醛向相应伯酰胺的有效转化。在非常短的反应时间内获得了优异的产率，因此该方法为传统的酰胺形成方法提供了一种有效的替代方法。

  DOI：

  10.1002/ejoc.201403280

文献信息

• [EN] CIS-IMIDAZOLINES AS MDM2 INHIBITORS<br/>[FR] CIS-IMIDAZOLINES INHIBITEURS DE MDM2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003051360A1

  公开（公告）日：2003-06-26

  The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity (I) (II).

  本发明提供了公式I和公式II的化合物及其药学上可接受的盐和酯，具有本文所提供的命名，并抑制MDM2蛋白与类p53肽的相互作用，并具有抗增殖活性。 (I)(II)。
• Indole derivatives useful for the treatment of diseases
  申请人：Brown Daniel Alan

  公开号：US20050085526A1

  公开（公告）日：2005-04-21

  The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  本发明涉及吲哚衍生物及其制备过程，用于制备中间体、含有该衍生物的组合物以及使用该衍生物的用途。根据本发明，这些吲哚衍生物在许多疾病、失调和状况中非常有用，特别是在炎症、过敏和呼吸系统疾病、失调和状况中。
• Cis-imidazolines
  申请人：Hoffmann-La Roche Inc.

  公开号：US06617346B1

  公开（公告）日：2003-09-09

  The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity

  本发明提供了公式I和公式II的化合物，以及其药学上可接受的盐和酯，具有本文提供的命名，并抑制MDM2蛋白与类p53肽的相互作用并具有抗增殖活性。
• Histone acetyltransferase activators and uses thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US11034647B2

  公开（公告）日：2021-06-15

  The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

  本发明提供了一种筛选与组蛋白乙酰转移酶蛋白结合并对其进行调节的化合物的方法。本发明进一步提供了通过向受试者施用 HAT 激活化合物来治疗神经退行性疾病、与淀粉样 beta 肽沉积、Tau 蛋白水平和/或 alpha-突触核蛋白累积有关的疾病以及癌症的方法。
• Soil metabolism of the herbicide isoxaben in winter wheat crops
  作者：Jean. Rouchaud、Fabrice. Gustin、Dany. Callens、Michel. Van Himme、Robert. Bulcke

  DOI：10.1021/jf00035a060

  日期：1993.11

  Winter wheat fields were treated wi th the herbicide isoxaben after sowing. Trials were made in 1990-1991 and 1991-1992. The main isoxaben soil metabolite was demethoxyisoxaben (N-[3-(1-ethyl-1-methylpropyl)isoxazol-5-yl]-2-hydroxy-6-methoxybenzamide), i.e., the monodemethoxylation product of isoxaben. 5-Isoxazolone(3-(1-ethyl-1-methylpropyl)isoxazolin-5-one) was the second main isoxaben metabolite. When 5-aminoisoxazole(5-amino-3-(1-ethyl-1-methylpropyl)isoxazole) was detected in soil, it always was at very low concentrations. It never accumulated in soil; 4 months before winter wheat harvest, it could not be detected in soil. Benzamides 2,6-dimethoxybenzamide and 2-hydroxy-6-methoxybenzamide and 2,6-dimethoxybenzoic acid also were detected in soil. Organic fertilizer treatments increased isoxaben soil persistence. At the crop's end, their effects, however, progressively disappeared, the soil residues of isoxaben and of its metabolites becoming very low and similar in the organic fertilizer treated and untreated plots. 5-Aminoisoxazole was not detected. This work thus indicated that isoxaben was soil-metabolized into nontoxic products, unable to generate toxic ones, during the wheat crops whose soil had been treated or not treated with organic fertilizers.