Naphthalen-1-yl-(4-pyrrol-1-ylphenyl)methanone | 147022-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Naphthalen-1-yl-(4-pyrrol-1-ylphenyl)methanone
• CAS: 147022-33-1
• 化学式: C₂₁H₁₅NO
• 分子量: 297.356
• InChiKey: WYQTWZPDTIYTCT-UHFFFAOYSA-N

物化性质

• 沸点：
  489.8±28.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Naphthalen-1-yl-(4-pyrrol-1-ylphenyl)methanone 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 1.0h， 生成 1-[1-Naphthyl-(4-pyrrol-1-ylphenyl)methyl]imidazole
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j
• 作为产物：
  描述：

  1-萘基(4-硝基苯基)甲酮 在 盐酸 、 tin(ll) chloride 作用下， 以 溶剂黄146 、 丙酮 为溶剂， 反应 2.83h， 生成 Naphthalen-1-yl-(4-pyrrol-1-ylphenyl)methanone
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j