[EN] BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION [FR] DÉRIVÉS DE BENZODIAZÉPINE UTILES DANS LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS RESPIRATOIRE SYNCYTIAL
The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
The present invention relates to compounds of general formula I,
wherein the groups R
1
, R
2
and m are defined as in claim
1
, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
[EN] NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS<br/>[FR] NOUVEAUX DÉRIVÉS D'ACIDE INDANYLOXYDIHYDROBENZOFURANNYLACÉTIQUE ET LEUR UTILISATION COMME AGONISTES DU RÉCEPTEUR GPR40
申请人:BOEHRINGER INGELHEIM INT
公开号:WO2013144098A1
公开(公告)日:2013-10-03
The present invention relates to compounds of general formula (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
[EN] SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 1<br/>[FR] VACCINS SYNTHÉTIQUES CONTRE LE STREPTOCOCCUS PNEUMONIAE DE TYPE 1
申请人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
公开号:WO2015004041A1
公开(公告)日:2015-01-15
The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae.
Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
申请人:Eckhardt Matthias
公开号:US20070049537A1
公开(公告)日:2007-03-01
Glucopyranosyl-substituted benzyl-benzene derivatives
of the general formula I
where the groups R
1
to R
6
as well as R
7a
, R
7b
, R
7c
are defined according to claim
1,
including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.