(E)-3-(4-(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-amine | 1376709-53-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-(4-(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-amine
• 英文别名: (E)-3-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]prop-2-en-1-amine
• CAS: 1376709-53-3
• 化学式: C₁₅H₂₅NOSi
• 分子量: 263.455
• InChiKey: SQZUYXQOGJIHGW-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.04
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-(4-(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-amine 、 diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以80%的产率得到diethyl 5-[[(E)-3-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]prop-2-enyl]carbamoylamino]-3-(2-phenylethyl)thiophene-2,4-dicarboxylate
  参考文献：
  名称：

  Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents

  摘要：

  Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant Gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE). Only one of these agents possessed moderate activity (16 -32 mg/L) against Gram-negative strains. An examination of the cytotoxicity of these agents revealed that they displayed low toxicity (40-50 mg/L) against mammalian cells and very low hemolytic activity (2-7%). Taken together, these studies suggest that thieno[2,3-d]pyrimidinediones are interesting scaffolds for the development of novel Gram-positive antibacterial agents. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.035
• 作为产物：
  描述：

  (E)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)acrylic acid 在 sodium azide 、 氢气 、 二异丁基氢化铝 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 反应 21.0h， 生成 (E)-3-(4-(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-amine
  参考文献：
  名称：

  Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents

  摘要：

  Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant Gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE). Only one of these agents possessed moderate activity (16 -32 mg/L) against Gram-negative strains. An examination of the cytotoxicity of these agents revealed that they displayed low toxicity (40-50 mg/L) against mammalian cells and very low hemolytic activity (2-7%). Taken together, these studies suggest that thieno[2,3-d]pyrimidinediones are interesting scaffolds for the development of novel Gram-positive antibacterial agents. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.035