6,7-bis(nitrooxy)heptanoic acid | 937808-80-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6,7-bis(nitrooxy)heptanoic acid
• 英文别名: 6,7-dinitrooxyheptanoic acid
• CAS: 937808-80-5
• 化学式: C₇H₁₂N₂O₈
• 分子量: 252.181
• InChiKey: YKRSWWHADLQSLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6,7-bis(nitrooxy)heptanoic acid 在 氯化亚砜 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (7-Chloro-1-nitrooxy-7-oxoheptan-2-yl) nitrate
  参考文献：
  名称：

  WO2007/60112

  摘要：

  公开号：
• 作为产物：
  描述：

  6-庚烯酸 在 碘 、 silver nitrate 作用下， 以 乙腈 为溶剂， 反应 12.5h， 以88%的产率得到6,7-bis(nitrooxy)heptanoic acid
  参考文献：
  名称：

  WO2007/60112

  摘要：

  公开号：

文献信息

• [EN] QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS<br/>[FR] COMPOSÉS DONNEURS D'OXYDE NITRIQUE À BASE DE QUINONE
  申请人：NICOX SCIENCE IRELAND

  公开号：WO2015155234A1

  公开（公告）日：2015-10-15

  The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.

  本发明涉及具有醌基结构的一氧化氮供体化合物，它们的制备方法以及它们在治疗和/或预防青光眼和眼压升高方面的用途。
• NEW NO-DONOR ASPIRIN DERIVATIVES
  申请人：Fruttero Roberta

  公开号：US20100210694A1

  公开（公告）日：2010-08-19

  The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.

  本发明涉及一种新的NO供体阿司匹林衍生物，其制备方法和包含它们的药物组合物。
• [EN] NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS DE PDE-5 ET/OU DE PDE-6 DONNEURS D'OXYDE D'AZOTE
  申请人：ILDONG PHARMACEUTICAL CO LTD

  公开号：WO2021094830A3

  公开（公告）日：2021-06-24
• [EN] NEW NO-DONOR ASPIRIN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'ASPIRINE DONNEURS NO
  申请人：NICOX SA

  公开号：WO2009049961A3

  公开（公告）日：2009-06-25
• Searching for New NO-Donor Aspirin-like Molecules: A New Class of Nitrooxy-acyl Derivatives of Salicylic Acid
  作者：Loretta Lazzarato、Monica Donnola、Barbara Rolando、Elisabetta Marini、Clara Cena、Gabriella Coruzzi、Elena Guaita、Giuseppina Morini、Roberta Fruttero、Alberto Gasco、Stefano Biondi、Ennio Ongini

  DOI：10.1021/jm701104f

  日期：2008.3.1

  A new class of products in which the phenol group of salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The products were stable in acid and neutral media, while they were hydrolyzed in human serum. Their half-lives were dependent upon the structure of alkanoyl moieties. The products showed anti-inflammatory activities similar to aspirin when tested in the carrageenan-induced paw edema assay in the rat. Interestingly, unlike aspirin, they showed reduced or no gastrotoxicity in a lesion model in rats at equimolar doses. A number of them were able to inhibit platelet aggregation induced by collagen in human platelet-rich plasma. All of the products were capable of relaxing rat aortic strips precontracted with phenylephrine in a concentration-dependent manner. Selected members of this new class of nonsteroidal anti-inflammatory drugs might represent possible safer alternatives to aspirin in different clinical settings.