linoleic acid | 4906-90-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: linoleic acid
• 英文别名: 8,11-Octadecadiensaeure；cis,cis-8,11-Octadiensaeure；8Z,11Z-octadecadienoic acid；(8Z,11Z)-octadeca-8,11-dienoic acid
• CAS: 4906-90-5
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.451
• InChiKey: WBTBKRBXTLZUJG-NQLNTKRDSA-N

物化性质

• 熔点：
  -16--15.5 °C
• 沸点：
  407.4±24.0 °C(Predicted)
• 密度：
  0.911±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  linoleic acid 在 溴 作用下， 以 Petroleum ether 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of Unsaturated Fatty Acids. Positional Isomers of Linoleic Acid¹

  摘要：

  DOI：

  10.1021/jo01040a023
• 作为产物：
  描述：

  1,6-二氯己烷 在 氨 、 二异丁基氢化铝 、 sodium iodide 作用下， 以 乙醚 、 正庚烷 为溶剂， 生成 linoleic acid
  参考文献：
  名称：

  Synthesis of Unsaturated Fatty Acids. Positional Isomers of Linoleic Acid¹

  摘要：

  DOI：

  10.1021/jo01040a023

文献信息

• Tripod-like Cationic Lipids as Novel Gene Carriers
  作者：Asier Unciti-Broceta、Emma Holder、Lisa J. Jones、Barbara Stevenson、Andrew R. Turner、David J. Porteous、A. Chris Boyd、Mark Bradley

  DOI：10.1021/jm701493f

  日期：2008.7.1

  An innovative family of tridentate-cationic "single-chained lipids" designed to enhance DNA compaction and to promote endosomal escape was synthesized by coupling various lipids to a multibranched scaffold. DNA retardation assays confirmed the ability of the most members of the library to complex DNA. Classical molecular dynamics simulations performed on the lauryl derivative, bound to a short strand of DNA in aqueous solution supported these observations. These showed that two "arms" of the tripodal molecule are ideally suited to forming strong Coulombic interactions with two contiguous phosphate groups from the DNA backbone while the lipophilic tail stays perpendicular to the DNA helix. Gene transfer abilities of the library were assessed in multiple cell lines (CHO, Cos7, and 16HBE14o-) with some library members giving excellent transfection abilities and low cytotoxicity, supporting the use of this tripodal approach for the development of efficient gene delivery agents.
• (17-ß)-3-OXOANDROST-4-EN-17-YL UNDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
  申请人：Lipocine Inc.

  公开号：US20160193225A1

  公开（公告）日：2016-07-07

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• PHARMACEUTICAL COMPOSITION AND METHODS
  申请人：Lipocine Inc.

  公开号：US20160184324A1

  公开（公告）日：2016-06-30

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• (17-ß)-3-Oxoandrost-4-En-17-Yl Undecanoate Compositions and Methods of Their Preparation and Use
  申请人：Lipocine Inc.

  公开号：US20180104257A1

  公开（公告）日：2018-04-19

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• Synthesis of Unsaturated Fatty Acids. Positional Isomers of Linoleic Acid¹
  作者：Walter J. Gensler、John J. Bruno

  DOI：10.1021/jo01040a023

  日期：1963.5