1,1,3,3,5,5-hexakis(4-(azidomethyl)phenoxy)cyclotriphosphazene | 1088354-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,3,3,5,5-hexakis(4-(azidomethyl)phenoxy)cyclotriphosphazene
• 英文别名: 2,2,4,4,6,6-Hexakis[4-(azidomethyl)phenoxy]-1,3,5-triaza-2lambda5,4lambda5,6lambda5-triphosphacyclohexa-1,3,5-triene；2,2,4,4,6,6-hexakis[4-(azidomethyl)phenoxy]-1,3,5-triaza-2λ5,4λ5,6λ5-triphosphacyclohexa-1,3,5-triene
• CAS: 1088354-56-6
• 化学式: C₄₂H₃₆N₂₁O₆P₃
• 分子量: 1023.81
• InChiKey: DYXBMODMBHDTEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17
• 重原子数：
  72
• 可旋转键数：
  24
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  179
• 氢给体数：
  0
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  1,1,3,3,5,5-hexakis(4-(azidomethyl)phenoxy)cyclotriphosphazene 、 1-乙炔基芘 在 五甲基二乙烯三胺 、 copper(I) bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 以90%的产率得到2,2,4,4,6,6-hexakis(4-((4-(pyren-1-yl)-1H-1,2,3-triazol-1-yl)methyl)phenoxy)-1,3,5,2l5,4l5,6l5-triazatriphosphinine
  参考文献：
  名称：

  通过“点击化学”合成末端封端的A6树枝状聚合物和具有磷腈核的星形聚合物

  摘要：

  新型六臂和pyr（Pyr）封端的磷腈树枝状聚合物[N 3 P 3-（Pyr）6 ]和具有聚（ε-己内酯）（PCL）臂的星形聚合物[N 3 P 3-（PCL- Pyr）通过两个系列的反应制备[ 6 ]。在这些系列中，从六羟基官能磷腈衍生物（N 3 P 3-（OH）6）开始使用了先核方法。在ε-己内酯的开环聚合反应中用作引发剂以制备六臂PCL星型聚合物（N 3 P 3-（PCL- OH）6）。N 3 P 3-（OH）6和N 3 P 3-（PCL- OH）6的羟基官能度随后成功地转化为溴化物和叠氮化物。叠氮化物官能树状大分子前体（N 3 P 3-（N 3）6）和星形聚合物（N 3 P 3-（PCL- N 3）6的进一步端基修饰）是在最后一步通过叠氮化物官能团和1-乙炔基1之间的Cu（I）催化的点击反应定量实现的。此外，the封端的磷腈树枝状聚合物和星形聚合物用于多壁碳纳米管的非共价官能化。©2011

  DOI：

  10.1002/pola.24756
• 作为产物：
  描述：

  hexakis(4-chloromethylphenoxy)cyclotriphosphazene 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到1,1,3,3,5,5-hexakis(4-(azidomethyl)phenoxy)cyclotriphosphazene
  参考文献：
  名称：

  双膦酸盐封端树枝状聚合物的设计

  摘要：

  报道了几种合成用生物活性氮杂二膦酸盐封端的磷树枝状聚合物的新方法。带有叠氮基或炔基的单体被设计为结构单元，用于连接到经典磷树枝状聚合物的表面或用于构建原始树枝状聚合物，而无需使用敏感的二氯（单甲基肼基）硫磷。

  DOI：

  10.1002/ejoc.200901291

文献信息

• Synthesis, structural characterization, and anion interactions of new triazole-linked urea derivative fully substituted cyclotriphosphazene compounds
  作者：Ozgur Ozay、Mehmet Yildirim、Hava Ozay

  DOI：10.1080/10426507.2016.1237950

  日期：2017.3.4

  GRAPHICAL ABSTRACT ABSTRACT Three novel fully substituted urea derivative cyclotriphosphazene compounds 5–7 were synthesized by alkyne-azide 1,3-dipolar cycloaddition reaction of propargyl substituted ureas 2–4 with hexaazide substituted cyclotriphosphazene 1 in the presence of Cu(I) catalyst. All compounds were characterized with spectroscopic techniques such as FT-IR, 1H, 13C, and 31P nuclear magnetic

  图形摘要 摘要 通过炔-叠氮化物 1,3-偶极环加成反应，炔-叠氮化物 2-4 与六叠氮化物取代的环三磷腈 1 在 Cu(I) 催化剂存在下，合成了三种新型的完全取代的脲衍生物环三磷腈化合物 5-7。所有化合物均采用光谱技术（如 FT-IR、1H、13C 和 31P 核磁共振和质谱）进行表征。此外，还通过 1H NMR 光谱研究了化合物 5-7 作为阴离子载体的有用性。为此，在四丁基氟化铵的 DMSO-d6 中记录了化合物 5-7 的 1H NMR 光谱。确定化合物中的尿素质子与氟化物相互作用。
• First Synthesis of “Majoral-Type” Glycodendrimers Bearing Covalently Bound α-<scp>d</scp>-Mannopyranoside Residues onto a Hexachlocyclotriphosphazene Core
  作者：Mohamed Touaibia、René Roy

  DOI：10.1021/jo801850f

  日期：2008.12.5

  A short and efficient strategy for the first synthesis of "Majoral-Type" multivalent glycodendrimers bearing covalently bound alpha-D-mannopyranosides onto a cyclotriphosphazene scaffold assembled using single-step Step Sonogashira and click chemistry is reported. New glycoclusters with valencies ranging from 6 to 18 and different epitope spatial arrangements were obtained. Cross-linking abilities of this series of glycodendrimers were evaluated with the model lectin from Canavalia ensiformis (Concanavalin A). The decameric mannoside 23, built around 19, was shown to be much faster in cross-linking the tetravalent lectin Concanavalin A than the positive control, which is the polysaccharide mannan from yeast. The new glycoconjugates reported may be promising tools as probes or effectors of biological processes involving multivalent carbohydrate-binding proteins.
• Phosphazene Based Multicentered Naked-Eye Fluorescent Sensor with High Selectivity for Fe³⁺ Ions
  作者：Reyhan Kagit、Mehmet Yildirim、Ozgur Ozay、Serkan Yesilot、Hava Ozay

  DOI：10.1021/ic402783x

  日期：2014.2.17

  A novel on/off fluorescent rhodamine-based hexapodal Fe3+ probe (L) containing a cyclotriphosphazene core was synthesized by an azide-alkyne "click-reaction". The synthesized compounds (1-5 and L) were characterized by FT-IR; H-1, C-13, and P-31 NMR; and MALDI MS spectrometry. The optical sensor features for the Fe3+ complex of L were investigated by UV-vis and fluorescence spectroscopy. The stoichiometry of L-Fe3+ complex was found to be 1:3 (ligand/metal ion), and the detection limit of L was determined as 4.8 mu M (0.27 mg L-1) for Fe3+ ions. The reusability of the sensor was tested by the addition of ethylenediamine to L-Fe3+ complex solutions followed by the addition of Fe3+ solution.
• Synthesis, Characterization, and Naked-Eye Sensor Application of Fully Substituted Urea-Based Cyclotriphosphazene Compound
  作者：Hava Ozay、Mehmet Yildirim、Ozgur Ozay

  DOI：10.1080/10426507.2015.1031752

  日期：2015.11.2

  A novel sensor with a hexacenter containing nitrophenylurea groups on a cyclotriphosphazene core was synthesized by click reaction of N-propargyl-substituted urea with a hexaazide-substituted cyclotriphosphazene compound. It was characterized by spectroscopic techniques such as Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. This compound was used for naked-eye and spectrophotometric detection of F- anions. The optical sensor properties of compound were investigated using ultraviolet-visible spectroscopy.
• Design of Bisphosphonate-Terminated Dendrimers
  作者：Emma Cavero、Maria Zablocka、Anne-Marie Caminade、Jean Pierre Majoral

  DOI：10.1002/ejoc.200901291

  日期：2010.5

  Several new methods for the synthesis of phosphorus dendrimers capped with biologically active azabisphosphonates are reported. Monomers bearing either azido or acetylenic groups were designed as building blocks either for attachment onto the surfaces of classical phosphorus dendrimers or for use in the construction of original dendrimers without the need for use of sensitive dichloro(monomethylhy

  报道了几种合成用生物活性氮杂二膦酸盐封端的磷树枝状聚合物的新方法。带有叠氮基或炔基的单体被设计为结构单元，用于连接到经典磷树枝状聚合物的表面或用于构建原始树枝状聚合物，而无需使用敏感的二氯（单甲基肼基）硫磷。