1-(5-Hydroxypentyl)imidazol | 72338-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(5-Hydroxypentyl)imidazol
• 英文别名: 5-imidazol-1-yl-pentan-1-ol；1H-Imidazole-1-pentanol；5-imidazol-1-ylpentan-1-ol
• CAS: 72338-61-5
• 化学式: C₈H₁₄N₂O
• 分子量: 154.212
• InChiKey: ICTYCNGFOUKSQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Nonpeptide agonists and antagonists of vasopressin receptors
  申请人：——

  公开号：US20020128208A1

  公开（公告）日：2002-09-12

  The disclosed invention is a composition agonists and/or antagonists of V 2 , V 1a or both receptors, in a host, including animals, and especially humans, using a small molecule or its pharmaceutically acceptable salt or prodrug.

  所披露的发明是在宿主中，包括动物，尤其是人类，使用小分子或其药用盐或前药，制备V2、V1a或两者受体的激动剂和/或拮抗剂的组合物。
• Phenylcarboxylic acid derivatives having a hetero ring
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0393607A2

  公开（公告）日：1990-10-24

  Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: wherein R¹ is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl, or imidazolylalkoxy; k is 0 or 1 to 3; or (R¹)k is alkylenedioxy; A is alkylene or alkylenoxy; ℓ is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R² is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of artherosclerosis, prophylactic and treating agent of obesity, antidiabetics.

  苯基羧酸衍生物，其取代基中含有一个杂环： 其中 R¹ 是卤素、烷基、环烷基、羟基、烷氧基、具有选自卤素和烷基的取代基的苯氧基、羧基、烷基磺酰氧基、任选被卤素取代的苯基磺酰氧基、烷基磺酰氧基烷氧基、氨基、烷酰氨基、苯甲酰氨基、烯氧基、苯基烷氧基烷氧基、羟基烷氧基、具有 1 至 3 个任选自卤素、烷基和烷氧基的取代基的苯基烷氧基、卤代烷基、任选 被羟基取代的环烷氧基、被具有任选羟基取代基的环烷基取代的烷氧基、咪唑烷基或咪唑烷氧基；A 是亚烷基或亚烷氧基；ℓ 是 0 或 1；B 是亚甲基或羰基；m 是 0 或 1；D 是亚烷基；E 是亚烷基或烯基；n 是 0 或 1；和 R² 是氢或烷基，或其盐，它们具有脂肪酸合成抑制活性和胆固醇合成抑制活性，可用作降血脂剂、动脉硬化的预防和治疗剂、肥胖的预防和治疗剂、抗糖尿病剂。
• VASOPRESSIN ANTAGONIST AND OXYTOCIN ANTAGONIST
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0620003A1

  公开（公告）日：1994-10-19

  A benzazepine compound represented by formulae (I) or (II) or a salt thereof, and a vasopressin antagonist or an oxytocin antagonist containing the above compound as the active ingredient.

  由式（I）或（II）代表的苯并氮杂卓化合物或其盐，以及含有上述化合物作为活性成分的血管加压素拮抗剂或催产素拮抗剂。
• Lp(a)-LOWERING AGENTS AND APOPROTEIN (a) PRODUCTION INHIBTORS
  申请人：TAIHO PHARMACEUTICAL COMPANY, LIMITED

  公开号：EP1000620A1

  公开（公告）日：2000-05-17

  Lp(a)-lowering agents or apo(a) production inhibitors containing as the active ingredient phenylcarboxylic acid derivatives represented by general formula (1) or salts thereof, wherein R1 represents optionally substituted phenyl; A represents lower alkylene or lower alkyleneoxy; B represents methylene or carbonyl; D represents lower alkylene; E represents lower alkylene or lower alkenylene; R2 represents hydrogen or lower alkyl; and l, m and n are each 0 or 1. These drugs can significantly lower Lp(a) while scarcely showing any side effects.

  Lp(a)降低剂或apo(a)生成抑制剂，其活性成分为通式(1)代表的苯基羧酸衍生物或其盐类，其中R1代表任选取代的苯基；A代表低级亚烷基或低级亚烷氧基；B代表亚甲基或羰基；D代表低级亚烷基；E代表低级亚烷基或低级亚烯基；R2代表氢或低级亚烷基；l、m和n均为0或1。这些药物可以大大降低脂蛋白（a），同时几乎没有任何副作用。
• Vasopressin antagonist and oxytocin antagonist
  申请人：Otsuka Pharmaceutical Company, Limited

  公开号：EP1902717A2

  公开（公告）日：2008-03-26

  An object of the present invention is to provide a vasopressin antagonist and oxytocin antagonist. The vasopressing antagonist and oxytocin antagonist according to the present invention contain, as the active ingredient, a benzoheterocyclic compound represented by the general formula (1): (wherein R1, R2, R3, R4, R5 and the carbon-carbon bond between 4- and 5-positions in the benzoazepine skeleton are the same as defined in Claims 1 and 2) or salt thereof.

  本发明的目的是提供一种血管加压素拮抗剂和催产素拮抗剂。 根据本发明，血管加压素拮抗剂和催产素拮抗剂含有通式（1）所代表的苯并杂环化合物作为活性成分： (其中 R1、R2、R3、R4、R5 和苯并氮杂卓骨架中 4 位和 5 位之间的碳-碳键与权利要求 1 和 2 中定义的相同）或其盐。