n-butyl dithioacetate | 69380-59-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: n-butyl dithioacetate
• 英文别名: Butyl ethanedithioate
• CAS: 69380-59-2
• 化学式: C₆H₁₂S₂
• 分子量: 148.293
• InChiKey: XRKBYEAPSWGBGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  n-butyl dithioacetate 、 异丁醛 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  A one-pot stereoselective synthesis of hydroxy-ketenedithioacetals from aldehydes

  摘要：

  The reaction of aldehydes with dithioacetate enethiolates followed by alkylation of the intermediate aldolate gives hydroxy-ketenedithioacetals with high stereoselectivity.

  DOI：

  10.1016/0040-4039(95)01268-m
• 作为产物：
  描述：

  正溴丁烷 、 二硫化碳 、 甲基碘化镁 生成 n-butyl dithioacetate
  参考文献：
  名称：

  Al-Awadi,N. et al., Journal of the Chemical Society. Perkin transactions II, 1978, p. 1223 - 1224

  摘要：

  DOI：

文献信息

• Stereoselective synthesis of hydroxy-ketenedithioacetals from aldehydes
  作者：Sylvie Tchertchian、Yannick Vallée

  DOI：10.1016/s0040-4020(98)00413-x

  日期：1998.7

  The reaction of Garner's aldehyde with dithioacetate enethiolates followed by alkylation of the intermediate aldolate gives hydroxy-ketenedithioacetals with a moderate anti selectivity. This methodology was applied to the synthesis of various other ketene dithioacetals with high E or Z stereoselectivity.

  Garner醛与二硫代乙酸乙烯酯的反应，然后将中间体醛缩酸酯烷基化，得到具有中等抗选择性的羟基-烯酮二硫缩醛。该方法学应用于具有高E或Z立体选择性的各种其他乙烯酮二硫缩醛的合成。
• Carboline Derivatives Useful in the Inhibition of Angiogenesis
  申请人：MOON Young-Choon

  公开号：US20070281962A2

  公开（公告）日：2007-12-06

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

  根据本发明，已经鉴定出了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。在本发明的一个方面，提供了在抑制VEGF产生、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性方面有用的化合物。在本发明的另一个方面，提供了使用本发明中的化合物抑制VEGF产生、抑制血管生成和/或治疗癌症、糖尿病视网膜病变或渗出性黄斑变性的方法。
• CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
  申请人：Moon Young-Choon

  公开号：US20100179132A1

  公开（公告）日：2010-07-15

  In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

  根据本发明，已经鉴定出抑制VEGF在转录后表达的化合物，并提供了它们的使用方法。本发明的一方面提供了用于抑制VEGF生产、治疗实体肿瘤癌和减少血浆和/或肿瘤VEGF水平的化合物。本发明的另一方面提供了使用本发明中的化合物抑制VEGF生产、治疗癌症和减少血浆和/或肿瘤VEGF水平的方法。
• The Azomethine Ylid Strategy in β-Lactam Synthesis. Application to Selenapenams
  作者：Giles A. Brown、Kirsty M. Anderson、Martin Murray、Timothy Gallagher、Neil J. Hales

  DOI：10.1016/s0040-4020(00)00408-7

  日期：2000.7

  Using azomethine ylid reactivity available from the beta-lactam-based oxazolidinone 1, selenoketones 6a-e react as 1,3-dipolarophiles to give racemic selenapenams 7a-e in a single step. The cycloaddition sequence proceeds with complete control of regiochemistry and the thermodynamically more stable C(3)/C(5) relationship is observed. The selenothiocarboxylate 9a and the selenocarboxylate 9b also function as effective dipolarophiles, but attempts to convert the resulting cycloadducts 10a and 10b to the corresponding selenapenems were unsuccessful. Other selenium-containing dipolarophiles failed to give characterizable cycloadducts. (C) 2000 Elsevier Science Ltd. All rights reserved.
• ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES
  申请人：Cao Liangxian

  公开号：US20100158858A1

  公开（公告）日：2010-06-24

  In accordance with the present invention, compounds are provided which are useful in a method or in the manufacture of a medicament for post-transcriptionally inhibiting the expression of VEGF in a subject in need thereof comprising inhibiting VEGF mRNA translation by orally administering said medicament once, twice or thrice daily to the subject.