4-<2-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>-3,5-dicarboethoxy-1,4-dihydrolutidine | 54280-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-<2-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>-3,5-dicarboethoxy-1,4-dihydrolutidine
• 英文别名: Diethyl 4-[2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 54280-80-7
• 化学式: C₂₆H₃₈N₂O₆
• 分子量: 474.598
• InChiKey: YWLXWOJMMFRZKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-[2-羟基-3-(叔丁基氨基)丙氧基]苯甲醛 、 乙酰乙酸乙酯 在 氨 作用下， 以 乙醇 为溶剂， 反应 15.0h， 生成 4-<2-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>-3,5-dicarboethoxy-1,4-dihydrolutidine
  参考文献：
  名称：

  Approaches to vasodilating/.beta.-adrenergic blocking agents: examples of the dihydrolutidine type

  摘要：

  The aminohydroxypropoxy moiety has been incorporated into the dihydrolutidine class of vasodilators. In the spontaneously hypertensive rat, one of these, (S)-4-[2-methyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3,5-dicarboethoxy-1,4-dihydrolutidine (4c), exhibited antihypertensive activity on the order of the standard 4-[2-(trifluoromethyl)phenyl]-3,5-dicarboethoxy-1,4-dihydrolutidine (2a). This antihypertensive activity could not be explained in terms of a vasodilating effect, as determined in the dog. In this latter model, 2a decreased both mean arterial and hindlimb perfusion pressures.

  DOI：

  10.1021/jm00137a028

文献信息

• Approaches to vasodilating/.beta.-adrenergic blocking agents: examples of the dihydrolutidine type
  作者：John J. Baldwin、R. Hirschmann、Edward L. Engelhardt、Gerald S. Ponticello、Charles S. Sweet、A. Scriabine

  DOI：10.1021/jm00137a028

  日期：1981.5

  The aminohydroxypropoxy moiety has been incorporated into the dihydrolutidine class of vasodilators. In the spontaneously hypertensive rat, one of these, (S)-4-[2-methyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3,5-dicarboethoxy-1,4-dihydrolutidine (4c), exhibited antihypertensive activity on the order of the standard 4-[2-(trifluoromethyl)phenyl]-3,5-dicarboethoxy-1,4-dihydrolutidine (2a). This antihypertensive activity could not be explained in terms of a vasodilating effect, as determined in the dog. In this latter model, 2a decreased both mean arterial and hindlimb perfusion pressures.