1H-pyrrol-2-yl(thiophen-2-yl)methanol | 1339730-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1H-pyrrol-2-yl(thiophen-2-yl)methanol
• CAS: 1339730-23-2
• 化学式: C₉H₉NOS
• 分子量: 179.243
• InChiKey: RUJSHECCAOBQLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  64.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  吡咯 、 1H-pyrrol-2-yl(thiophen-2-yl)methanol 在 三氟化硼乙醚 作用下， 反应 0.16h， 生成 5-(2-thienyl)dipyrromethane
  参考文献：
  名称：

  Efficient Synthesis of Bis(heterocyclyl)methanes

  摘要：

  The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.

  DOI：

  10.1080/00397911.2010.518330
• 作为产物：
  描述：

  2-吡咯甲醛 、 magnesium,2H-thiophen-2-ide,bromide 以 乙醚 为溶剂， 生成 1H-pyrrol-2-yl(thiophen-2-yl)methanol
  参考文献：
  名称：

  Efficient Synthesis of Bis(heterocyclyl)methanes

  摘要：

  The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.

  DOI：

  10.1080/00397911.2010.518330

文献信息

• THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1072266A1

  公开（公告）日：2001-01-31

  The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.

  噻唑烷氧基乙胺（I），其中 R1 是氢原子、卤素原子或低级烷基；R2、R3 和 R4 分别代表氢原子或低级烷基；Az 代表含有 1 至 3 个氮原子的 N-甲基取代的五元氮杂环芳香基团。它们对包括人类在内的哺乳动物具有镇痛活性。例如，通过羟基噻吩唑的衍生物（IV）与合适的 N-（乙基）胺的衍生物反应，可以得到化合物（I）。化合物（IV）是合成化合物（I）的有用中间体。化合物 (I) 可应用于人类和/或兽医领域。
• Thienylazolylalkoxyethanamines, their preparation and their application as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：US20020188017A1

  公开（公告）日：2002-12-12

  The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.

  噻唑烷氧基乙胺（I），其中 R1 是氢原子、卤素原子或低级烷基；R2、R3 和 R4 分别代表氢原子或低级烷基；Az 代表含有 1 至 3 个氮原子的 N-甲基取代的五元氮杂环芳香基团。 它们对包括人类在内的哺乳动物具有镇痛活性。 例如，通过羟基噻吩唑的衍生物（IV）与合适的 N-（乙基）胺的衍生物反应，可以得到化合物（I）。 化合物（IV）是合成化合物（I）的有用中间体。 化合物 (I) 可应用于人类和/或兽医领域。
• US6410582B1
  申请人：——

  公开号：US6410582B1

  公开（公告）日：2002-06-25
• US7129361B2
  申请人：——

  公开号：US7129361B2

  公开（公告）日：2006-10-31
• Efficient Synthesis of Bis(heterocyclyl)methanes
  作者：Kamaljit Singh、Shivali Sharma、Amit Sharma

  DOI：10.1080/00397911.2010.518330

  日期：2011.12.1

  The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.