DL-β-amino decanoic acid | 116496-49-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-β-amino decanoic acid
• 英文别名: 3-amino-decanoic acid；3-Amino-decansaeure；3-Amino-caprinsaeure；3-Aminodecanoic acid
• CAS: 116496-49-2
• 化学式: C₁₀H₂₁NO₂
• mdl: MFCD00123306
• 分子量: 187.282
• InChiKey: SSKFRIVYCVHCQK-UHFFFAOYSA-N

物化性质

• 熔点：
  205-206 °C(Solv: ethanol (64-17-5))
• 沸点：
  305.7±25.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-β-amino decanoic acid 在 sodium hydroxide 、 氯化亚砜 作用下， 生成 (1-carbamoylmethyl-octyl)-carbamic acid ethyl ester
  参考文献：
  名称：

  Rodionow et al., Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1794,1798; engl. Ausg. S. 1893, 1896

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基(E)-2-癸烯酸酯 在 吡啶 、 氢氧化钾 、 sodium ethanolate 作用下， 反应 28.0h， 生成 DL-β-amino decanoic acid
  参考文献：
  名称：

  Laxaphycins的总体结构和对肿瘤细胞增殖的抑制作用。

  摘要：

  我们从富含Lyngbya majuscula的海洋蓝细菌的混合组合中分离了一系列细胞生长抑制性环肽。通过光谱方法和降解分析确定了两种主要成分拉沙霉素A（1）和B（2）以及两种次要肽拉沙霉素B2（3）和B3（4）的结构。天然和非蛋白质氨基酸的绝对构型是通过水解，非商业残基合成，化学衍生和HPLC分析的组合来确定的。产生laxaphycins的生物被鉴定为蓝藻鱼腥藻。在一组固态和淋巴母细胞癌细胞上研究了拉沙霉素的抗增殖活性。我们的结果表明，与拉沙霉素A相比，

  DOI：

  10.1021/jm061307x

文献信息

• Process for producing optically active 3-halogenocarboxylic acid ester and 3-azidocarboxylic acid ester
  申请人：——

  公开号：US20030225301A1

  公开（公告）日：2003-12-04

  A process for producing an optically active 3-azide-carboxylic acid ester by reacting an optically active 3-hydroxycarboxylic acid ester and a thionyl halide in the presence of a basic substance in an organic solvent to produce an optically active 3-halogenocarboxylic acid ester which is then reacted with an azide salt represented by the formula: MN 3 (wherein M is an alkaline metal) in water or a mixture of water and a water soluble organic solvent.

  通过在有机溶剂中，在碱性物质存在下，将光学活性的3-羟基羧酸酯和硫酰卤在一起反应，产生光学活性的3-卤代羧酸酯，然后将其与由公式表示的偶氮盐（其中M是碱性金属）在水或水和水溶性有机溶剂的混合物中反应，从而生产光学活性的3-偶氮基羧酸酯的方法。
• Novel dioctatin derivatives and production process thereof
  申请人：Muraoka Yasuhiko

  公开号：US20080312080A1

  公开（公告）日：2008-12-18

  To provide dioctatin derivatives, a production process thereof, an aflatoxin production inhibitor containing the dioctatin derivative, and a method of controlling aflatoxin contamination by use of the aflatoxin production inhibitor containing the dioctatin derivative. The present invention provides dioctatin derivatives represented by the following Structural Formula (I): where R 1 and R 2 each represent CH 3 —(CH 2 ) n —, (CH 3 ) 2 CH—CH 2 — or C 6 H 5 —CH 2 —; n represents an integer of 2 to 6; X 1 and X 2 each represent CH 3 or hydrogen atom; and Y represents 2-amino-2-butenoic acid or amino acid residue, with compounds where R 1 and R 2 are each CH 3 (CH 2 ) 4 —, X 2 is a hydrogen atom and Y is 2-amino-2-butenoic acid being excluded.

  提供二辛酸衍生物、其生产工艺、含有二辛酸衍生物的黄曲霉毒素生产抑制剂，以及利用含有二辛酸衍生物的黄曲霉毒素生产抑制剂控制黄曲霉素污染的方法。本发明提供了由以下结构式（I）表示的二辛酸衍生物： 其中R1和R2分别代表CH3—(CH2)n—、(CH3)2CH—CH2—或C6H5—CH2—；n代表2至6的整数；X1和X2分别代表CH3或氢原子；Y代表2-氨基-2-丁烯酸或氨基酸残基，其中排除了R1和R2均为CH3(CH2)4—、X2为氢原子且Y为2-氨基-2-丁烯酸的化合物。
• Process for producing optically active 3-halogenocarboxylic acid esters and 3-azide-carboxylic acid esters
  申请人：Takasago International Corporation

  公开号：EP1344763A1

  公开（公告）日：2003-09-17

  A process for producing an optically active 3-azide-carboxylic acid ester by reacting an optically active 3-hydroxycarboxylic acid ester and a thionyl halide in the presence of a basic substance in an organic solvent to produce an optically active 3-halogenocarboxylic acid ester which is then reacted with an azide salt represented by the formula: MN3 (wherein M is an alkaline metal) in water or a mixture of water and a water soluble organic solvent.

  一种生产光学活性 3-叠氮羧酸酯的工艺，在有机溶剂中，在碱性物质存在下，使光学活性 3-羟基羧酸酯和硫酰基卤反应，生成光学活性 3-卤代羧酸酯，然后使其与式 MN3（其中 M 为碱金属）代表的叠氮盐反应：MN3（其中 M 为碱金属）在水或水与水溶性有机溶剂的混合物中反应。
• Manufacture and use of an antibiotic/antibiotics preparation
  申请人：Heraues Kulzer GmbH & Co.KG

  公开号：US20020183265A1

  公开（公告）日：2002-12-05

  The present invention concerns the manufacture and use of an antibiotic/antibiotics preparation for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The manufacture in accordance with the invention of an antibiotic/antibiotics preparation takes place according to the invention in that water, an amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates, one or more antibiotic components from the group of aminoglycoside antibiotics, lincosamide antibiotics and tetracycline antibiotics, an organic auxiliary component and/or an inorganic auxiliary component and if need be at least one biologically active component are mixed together and shaped into molded elements, granulates, powders, foils, shaped masses and threads.

  本发明涉及一种用于治疗硬组织和软组织局部微生物感染的人类和兽医抗生素/抗生素制剂的制造和使用。烷基环烷基硫酸盐、烷基氨基磺酸盐、环烷基氨基磺酸盐、烷基环烷基氨基磺酸盐、芳基氨基磺酸盐、烷芳基氨基磺酸盐、烷基磺酸盐、脂肪酸-2-磺酸盐、芳基磺酸盐、烷芳基磺酸盐、环烷基磺酸盐、环烷基磺酸盐、烷基环烷基磺酸盐、烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐、环烷基二硫酸盐烷基二磺酸盐、环烷基二磺酸盐、烷基二磺酸盐、环烷基二磺酸盐、芳基二磺酸盐、 烷芳基二磺酸盐、芳基三磺酸盐和烷芳基三磺酸盐； 氨基糖苷类抗生素中的一种或多种抗生素成分、林可酰胺类抗生素和四环素类抗生素中的一种或多种抗生素成分、一种有机辅助成分和/或一种无机辅助成分，必要时还包括至少一种生物活性成分。
• Antibiotic(s) preparation with retarding active ingredient release
  申请人：Heraues Kulzer GmbH & Co.KG

  公开号：US20020182251A1

  公开（公告）日：2002-12-05

  The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The invented antibiotic/antibiotics preparation is a mixture consisting of at least one amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates as well as at least one antibiotic component from the group of aminoglycoside antibiotics, lincosamide antibiotics, 4-quinolone antibiotics and tetracycline antibiotics, and if need be at least one anhydrous organic auxiliary component and if need be at least one inorganic auxiliary component and if need be at least one biologically active component. The antibiotic/antibiotics preparation of the invention has a retarding active ingredient release.

  本发明涉及一种抗生素/抗菌剂制剂，用于人类和兽医的可吸收和不可吸收植入物，以治疗硬组织和软组织的局部微生物感染。本发明的抗生素/抗菌剂制剂是一种混合物，由烷基硫酸盐、芳基硫酸盐、烷芳基硫酸盐、环烷基硫酸盐、烷基环烷基硫酸盐、烷基氨基磺酸盐中具有代表性的至少一种两亲成分组成、环烷基氨基磺酸盐、烷基环烷基氨基磺酸盐、芳基氨基磺酸盐、烷芳基氨基磺酸盐、烷基磺酸盐、脂肪酸-2-磺酸盐、芳基磺酸盐、烷芳基磺酸盐、环烷基磺酸盐、烷基环烷基磺酸盐、烷基二硫酸盐、环烷基二磺酸盐、烷基二磺酸盐、环烷基二磺酸盐、芳基二磺酸盐、烷芳基二磺酸盐、 芳基三磺酸盐和烷芳基三磺酸盐，以及氨基糖苷类抗生素中的至少一种抗生素成分、林可酰胺类抗生素、4-喹诺酮类抗生素和四环素类抗生素中的至少一种抗生素成分，以及至少一种无水有机辅助成分（如有必要）和至少一种无机辅助成分（如有必要），以及至少一种生物活性成分（如有必要）。本发明的抗生素/抗生素制剂具有延缓活性成分释放的作用。