2H-1-苯并吡喃-3(4H)-酮,7-甲氧基-2-苯基- | 105849-83-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 2H-1-苯并吡喃-3(4H)-酮,7-甲氧基-2-苯基-
• 英文名称: 7-methoxy-2-phenyl-4H-chromen-3-one
• CAS: 105849-83-0
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: CIWLNSUJDUACGC-UHFFFAOYSA-N

物化性质

• 沸点：
  427.4±45.0 °C(Predicted)
• 密度：
  1.199±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-甲氧基-3-硝基-2-苯基-2H-苯并吡喃 在 chromium dichloride 、 盐酸 、 sodium tetrahydroborate 作用下， 生成 2H-1-苯并吡喃-3(4H)-酮,7-甲氧基-2-苯基-
  参考文献：
  名称：

  Rao, T. Sudhakar; Trivedi, G. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1159 - 1160

  摘要：

  DOI：

文献信息

• Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
  申请人：Gomtsyan Arthur

  公开号：US20060128689A1

  公开（公告）日：2006-06-15

  Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A 1 , A 2 , A 3 , A 4 , R 7 , R 8 , R 9 , X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

  对VR1受体拮抗剂，其化学式为(I)或其药用可接受的盐、前药或前药的盐，其中A1、A2、A3、A4、R7、R8、R9、X、Y、Z、L、n和m的定义如本文所述，并且在通过抑制VR1受体预防或改善的疾病中具有用处。
• Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
  申请人：Ziegler Hugo

  公开号：US20070099842A1

  公开（公告）日：2007-05-03

  The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R 1 represents H, —C(O)—R 6 , —SO 2 —R 6 or —C(O)—XR 6 ; R 2 and R 4 , independent of one another, represent (CH 2 ) n —NH 2 or (CH 2 ) 3 —NHC(NH)NH 2 ; n equals 1 4; R 3 represents linear or branched C 1 -C 4 alkyl that is optionally substituted by hydroxy; R 5 and R 6 , independent of one another, represent hydrogen, optionally substituted (C 1 -C 24 ) alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C 1 -C 4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR 5 with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R 1 and R 5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

  该发明涉及化合物及其在化妆品中可接受的盐，其对应于一般式(I)，其中：R1代表H，—C(O)—R6，—SO2—R6或—C(O)—XR6；R2和R4，彼此独立，代表(CH2)n—NH2或(CH2)3—NHC(NH)NH2；n等于1至4；R3代表线性或支链的C1-C4烷基，可选择地被羟基取代；R5和R6，彼此独立，代表氢，可选择地被取代的(C1-C24)烷基，可选择地被取代的C2-C24烯基，可选择地被取代的苯基，可选择地被取代的苯基-C1-C4烷基或9-芴基甲基；X代表氧(—O—)或—NH—；或XR5，其中X=O也代表α-生育酚、生育三烯酚或视黄醇的酯，条件是R1和R5不同时代表氢，X不同时代表氧。该发明还涉及制备一般式(I)化合物以及含有至少一种一般式(I)化合物的化妆品活性组合物。
• Branched Polymeric Emulsifiers
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US20150218312A1

  公开（公告）日：2015-08-06

  The present invention relates to esterified glycerylated alkyl glycoside and to a process for making same. The esterified glycerylated alkyl glycoside have one or more polyglyceryl moieties and one or more acyl moieties, wherein all of the one or more acyl moieties are situated on the one or more polyglyceryl moieties via an ester linkage. These compounds have been found to be useful as emulsifiers and coemulsifiers in the formulation of a phase stable emulsions suitable for use in personal care, home care, industrial and institutional, and health care applications.

  本发明涉及酯化的甘油化烷基葡糖苷以及制备该化合物的方法。所述的酯化的甘油化烷基葡糖苷具有一个或多个聚甘油基团和一个或多个酰基团，其中所有的一个或多个酰基团通过酯键位于一个或多个聚甘油基团上。已发现这些化合物在制备适用于个人护理、家庭护理、工业和机构、以及医疗保健应用的相稳定乳化剂和共乳化剂方面具有实用性。
• Personal care articles comprising hotmelt compositions
  申请人：——

  公开号：US20010018068A1

  公开（公告）日：2001-08-30

  The present invention relates to a substantially dry, disposable personal care article suitable for cleansing, said article comprising: a) a water insoluble substrate comprising a creped nonwoven layer; and b) a cleansing component disposed adjacent to said creped nonwoven layer, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant and wherein the cleansing component exhibits a log [(&eegr; @ 25° C.)/(&eegr; @ 200° C.)] greater than about 0.45. Additionally, the present invention relates to a similar article that is characterized by a cleansing component that exhibits a complex viscosity measured under an oscillation stress of 1 Pa of greater than about 100 Pa·s. at 25° C. The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit component in addition to or in lieu of the cleansing component. These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invention further relates to methods of cleansing and conditioning the skin and hair utilizing the articles of the present invention.

  本发明涉及一种适用于清洁的基本干燥、一次性个人护理用品，该用品包括： a）一种水不溶性基材，包括一个褶皱无纺布层；和 b）位于所述褶皱无纺布层相邻的清洁成分，其中所述成分包括从水不溶性基材的重量约10％到约1000％的起泡表面活性剂，且所述清洁成分的对数[（&eegr; @ 25℃）/（&eegr; @ 200℃）]大于约0.45。 此外，本发明还涉及一种类似的用品，其特征在于清洁成分在25℃下测量的振荡应力大于约100 Pa·s的复杂黏度。本发明进一步涉及一种适用于调理的基本干燥、一次性个人护理用品，其中上述所述的用品包括治疗益处成分，位于所述水不溶性基材相邻的位置，其中所述成分包括从水不溶性基材的重量约10％到约1000％的治疗益处成分，除了或代替清洁成分。 已经发现这些用品在个人清洁应用中特别有用，即用于皮肤和头发。因此，本发明还涉及利用本发明的用品清洁和调理皮肤和头发的方法。
• CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF
  申请人：Gomtsyan Arthur

  公开号：US20110152250A1

  公开（公告）日：2011-06-23

  Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A 1 , A 2 , A 3 , A 4 , R 7 , R 8 , R 9 , X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

  具有以下式子（I）或其药学上可接受的盐、前药或前药的盐的拮抗VR1受体的化合物，在其中A1、A2、A3、A4、R7、R8、R9、X、Y、Z、L、n和m如本文所定义，并且在抑制VR1受体有益于预防或改善疾病。