2-(1-Methylamino-2-hydroxy-ethyl)-furan | 2745-18-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(1-Methylamino-2-hydroxy-ethyl)-furan
• 英文别名: I(2)-(Methylamino)-2-furanethanol；2-(furan-2-yl)-2-(methylamino)ethanol
• CAS: 2745-18-8
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: DTCAJMPSUPDOKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  92-93 °C(Press: 1 Torr)
• 密度：
  1.0871 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  45.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [[1-(2-furyl)ethenyl]oxy]tri-isopropylsilane 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 (1S,2S)-(+)-N-对甲苯磺酰基-1,2-二苯基乙二胺 N-氯代丁二酰亚胺 、 甲酸 、 氢氟酸 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 20.5h， 生成 2-(1-Methylamino-2-hydroxy-ethyl)-furan
  参考文献：
  名称：

  Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

  摘要：

  As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general approach had not yet been reported, encouraging us to undertake the development of such a methodology. This study describes the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-aryl-2-methylaminoethanols. Of particular importance were observations of the impact of solvent and the method of catalyst preparation on the yield and enantiomerical excess of chlorohydrins prepared via Noyori transfer hydrogenations of aryl-chloromethyl ketones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.017

文献信息

• PYRIDOQUINOXALINE ANTIVIRALS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1458719A1

  公开（公告）日：2004-09-22
• 4-OXO-4,7-DIHYDROFURO(2,3-B)PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1465895A2

  公开（公告）日：2004-10-13
• OXOTHIENO[3,2-B]PYRIDINECARBOXAMIDES AS ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1467999A1

  公开（公告）日：2004-10-20
• THIENO(3,2-B)PYRIDONES AS ANTIVIRAL COMPOUNDS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1472260A2

  公开（公告）日：2004-11-03
• [EN] PYRIDOQUINOXALINE ANTIVIRALS<br/>[FR] ANTIVIRAUX A BASE DE PYRIDOQUINOXALINE
  申请人：UPJOHN CO

  公开号：WO2003053971A1

  公开（公告）日：2003-07-03

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R?1, R2 and R3¿ are as defined in the specification. The compounds are useful for the treatment of viral infections.