(R)-benzyl butan-2-yl ether | 59901-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-benzyl butan-2-yl ether
• 英文别名: [(2R)-butan-2-yl]oxymethylbenzene
• CAS: 59901-79-0
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: LCQVWUUQYVVDLN-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-benzyl butan-2-yl ether 、 六羰基铬 以73%的产率得到η6-[(R)-(-)-benzyl butan-2-yl ether]tricarbonylchromium(O)
  参考文献：
  名称：

  Blagg, Julian; Davies, Stephen G.; Holman, Nicholas J., Journal of the Chemical Society. Perkin transactions I

  摘要：

  DOI：
• 作为产物：
  描述：

  (R)-3-benzyloxy-2-butanone 在 三氟化硼乙醚 、 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 (R)-benzyl butan-2-yl ether
  参考文献：
  名称：

  Synthesis and Lewis Acid-Catalyzed Nucleophilic Substitution of Chiral 1-Alkoxyalkyl Carboxylates

  摘要：

  DOI：

  10.1021/ja970153v

文献信息

• DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initation factor 5A, transgenic plants and a method for controlling senescene and programmed cell death in plants
  申请人：Senesco, Inc.

  公开号：EP1881072A1

  公开（公告）日：2008-01-23

  Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced elF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced elF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

  通过将编码衰老诱导脱氧羽扇豆碱合成酶、衰老诱导 elF-5A 或两者的基因或基因片段以反义方向整合到植物基因组中，可实现对植物中程序性细胞死亡（包括衰老）表达的调控。鉴定了编码衰老诱导的脱氧羽扇豆碱合成酶和衰老诱导的 elF-5A 的植物基因，并利用每种基因单独或组合的核苷酸序列来改变转基因植物的衰老。
• Blagg, Julian; Davies, Stephen G.; Holman, Nicholas J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1581 - 1590
  作者：Blagg, Julian、Davies, Stephen G.、Holman, Nicholas J.、Laughton, Charles A.、Mobbs, Bryan E.

  DOI：——

  日期：——
• Blagg, Julian; Davies, Stephen G.; Holman, Nicholas J., Journal of the Chemical Society. Perkin transactions I
  作者：Blagg, Julian、Davies, Stephen G.、Holman, Nicholas J.、Laughton, Charles A.、Mobbs, Bryan E.

  DOI：——

  日期：——
• BLAGG J.; DAVIES S. G.; HOLMAN N. J.; LAUGHTON CH. A.; MOBBS B. E., J. CHEM. SOC. PERKIN TRANS.,(1986) N 9, 1581-1589
  作者：BLAGG J.、 DAVIES S. G.、 HOLMAN N. J.、 LAUGHTON CH. A.、 MOBBS B. E.

  DOI：——

  日期：——
• [EN] TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS<br/>[FR] DÉRIVÉS DE TÉTRAHYDRONAPHTALÈNE ET DE TÉTRAHYDROISOQUINOLÉINE EN TANT QU'AGENTS DE DÉGRADATION DES RÉCEPTEURS DES ŒSTROGÈNES
  申请人：ARVINAS INC

  公开号：WO2018102725A1

  公开（公告）日：2018-06-07

  The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.