N-acetylnicotinamide | 80893-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-acetylnicotinamide
• 英文别名: acetyl-nicotinoyl-amine；Acetyl-nicotinoyl-amin；N-Acetylpyridine-3-carboxamide
• CAS: 80893-78-3
• 化学式: C₈H₈N₂O₂
• 分子量: 164.164
• InChiKey: IOHVMKKVKVRCBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetylnicotinamide 在 乙酸酐 、 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 反应 15.0h， 生成 3-吡啶甲酰胺,N-乙酰基-1,2-二氢-2-羰基-
  参考文献：
  名称：

  Nagano, Hiroyuki; Nawata, Yoshiharu; Hamana, Masatomo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 10, p. 4068 - 4077

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(乙酰氨基甲基)嘧啶 在 N-羟基邻苯二甲酰亚胺 、 氧气 、 2,4,6-三甲基吡啶高氯酸盐 作用下， 以 丙酮 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 以73%的产率得到N-acetylnicotinamide
  参考文献：
  名称：

  NHPI-Mediated Electrochemical α-Oxygenation of Amides to Benzimides

  摘要：

  DOI：

  10.1021/acs.joc.2c02700

文献信息

• METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2380989A1

  公开（公告）日：2011-10-26

  The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.

  本发明提供了一种测量试液中分析物浓度的方法，其中分析物为甲羟戊酸和/或3-羟甲基戊二酰辅酶A，该方法包括以下步骤(p)和(q)：(p) 让催化反应式 1 所代表的反应的酶和催化反应式 2 所代表的反应的酶在氢受体 X、氢供体 Y 和辅酶 A 的存在下作用于含有甲羟戊酸和/或 3-羟甲基戊二酰辅酶 A 的试液的步骤；和 (q) 测量以下物质的量的步骤：产生的还原氢受体 X；或产生的氧化氢供体 Y；或减少的氢受体 X；或减少的氢供体 Y，其中氢供体 Y 和还原氢受体 X 并不相同。
• Rayet, Industrie Chimique Belge, 1952, vol. 17, p. 478
  作者：Rayet

  DOI：——

  日期：——
• NAGANO, HIROYUKI;NAWATA, YOSHIHARU;HAMANA, MASATOMO, CHEM. AND PHARM. BULL., 35,(1987) N 10, 4068-4077
  作者：NAGANO, HIROYUKI、NAWATA, YOSHIHARU、HAMANA, MASATOMO

  DOI：——

  日期：——
• [EN] PHARMACEUTICAL APPLICATIONS OF HYDROTROPIC AGENTS, POLYMERS THEREOF, AND HYDROGELS THEREOF<br/>[FR] APPLICATIONS PHARMACEUTIQUES D'AGENTS HYDROTROPES, POLYMERES ET HYDROGELS DE CES DERNIERS
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2002030466A2

  公开（公告）日：2002-04-18

  The present invention is directed to compounds effective for increasing the water solubility of poorly soluble drugs. Hydrotropic agents are identified, such as for increasing the solubility of paclitaxel. Polymerizable monomers of the hydrotropic agents are prepared and hydrotropic polymers formed from such monomers are generated. Both the monomers and resulting polymers increase the solubility of poorly soluble drugs. In some cases, the hydrotropic polymers are more effective at increasing solubility at low concentrations relative to a corresponding amount of the hydrotropic agent precursor. Additionally, the hydrotropic polymers (hytrops) can be crosslinked to yield hydrotropic hydrogels (hytrogels) capable of solubilizing a drug. The hytrogels can further be employed to generate micro-and nano-particle suspensions of a poorly soluble drug. The water solubility of paclitaxel can be increased by four orders of magnitude using compounds of the invention. Large molecular weight compounds, such as the hytrops and hytrogels, are expected to have low levels of absorption in the gastrointestinal tract, thereby making them particularly preferred for oral delivery of poorly soluble drugs.
• Nagano, Hiroyuki; Nawata, Yoshiharu; Hamana, Masatomo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 10, p. 4068 - 4077
  作者：Nagano, Hiroyuki、Nawata, Yoshiharu、Hamana, Masatomo

  DOI：——

  日期：——