2，6-二氯吡啶-4-偕胺肟盐酸盐 | 175204-59-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2，6-二氯吡啶-4-偕胺肟盐酸盐
• 中文别名: 2,6-二氯吡啶-4-羧酰胺盐酸盐
• 英文名称: 2,6-dichloropyridine-4-carboximidamide hydrochloride
• 英文别名: 2,6-dichloropyridine-4-carboximidamide;hydrochloride
• CAS: 175204-59-8
• 化学式: C₆H₅Cl₂N₃*ClH
• 分子量: 226.493
• InChiKey: UUYKXMZAQVBDQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xn,Xi
• 危险类别码：
  R22,R36/37/38
• 安全说明：
  S26,S37/39
• 海关编码：
  2933399090

SDS

Name:	2 6-Dichloropyridine-4-carboximidamide hydrochloride 95+% Material Safety Data Sheet
Synonym:
CAS:	175204-59-8

Section 1 - Chemical Product MSDS Name:2 6-Dichloropyridine-4-carboximidamide hydrochloride 95+% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
175204-59-8	2,6-Dichloropyridine-4-carboximidamide	95+%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 175204-59-8: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 263 - 265 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H6Cl3N3
Molecular Weight: 226

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases, acid chlorides.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide, ammonia.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 175204-59-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,6-Dichloropyridine-4-carboximidamide hydrochloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 175204-59-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 175204-59-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 175204-59-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-甲氧基(全氟基-2-甲基-1-丙烯) 、 2，6-二氯吡啶-4-偕胺肟盐酸盐 在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 46.0h， 以51.7%的产率得到6-fluoro-4-methoxy-2-(2,6-dichloro-4-pyridyl)-5-trifluoromethylpyrimidine
  参考文献：
  名称：

  FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND METHOD FOR MANUFACTURING THE SAME

  摘要：

  提供一种含氟嘧啶化合物，其通式表示为(1)、(2)、(3)、(4)、(5)或(6)，其中，在上述通式(1)到(6)中，R代表具有1到12个碳原子的烃基；X和Y各自独立地表示氢原子、卤素原子、具有1到10个碳原子的烃基、-CnF2n+1(n为1到10的整数)、硝基、硼酸酯基、-OA1、-SOmA1(m为0到3的整数)、-NA1A2、-COOA1或-CONA1A2，其中A1和A2各自独立地表示氢原子或具有1到10个碳原子的烃基。

  公开号：

  US20210403455A1

文献信息

• 2-aryl-5,6-dihydropyrimidinones and herbicidal use thereof
  申请人：Rohm and Haas Company

  公开号：US05629264A1

  公开（公告）日：1997-05-13

  A class of 2-aryl-5,6-dihydropyrimidinones and compositions thereof which are useful in the control of weeds is of the general formula ##STR1## wherein Ar is a substituted or unsubstituted aryl or heteroaryl; R.sup.3 is an optionally substituted alkyl, alkenyl or alkynyl; R.sup.5a and R.sup.5b are each independently a hydrogen atom, halo, cyano or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthio; R.sup.6a and R.sup.6b are each independently a hydrogen atom, halo, cyano, an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthioalkyl, cycloalkyl, optionally substituted aryl, aryloxy, heterocyclyl or aralkyl, alkylamino, dialkylamino or dialkylaminocarbonyl; R.sup.5a and R.sup.6a taken together with the carbon atoms to which they are attached may form a fused 4-7 member ring containing 2-5 methylenes; and X is an oxygen or a sulfur atom.

  一类2-芳基-5,6-二氢嘧啶酮及其组合物，可用于控制杂草，其一般公式为##STR1##其中，Ar是取代或未取代的芳基或杂环芳基；R.sup.3是可选取代的烷基，烯基或炔基；R.sup.5a和R.sup.5b分别独立地是氢原子，卤素，氰基或可选取代的烷基，烯基，炔基，烷氧基或烷硫基；R.sup.6a和R.sup.6b分别独立地是氢原子，卤素，氰基，可选取代的烷基，烯基，炔基，烷氧基或烷硫基烷基，环烷基，可选取代的芳基，芳氧基，杂环芳基或芳基烷基，烷基氨基，二烷基氨基或二烷基氨基羰基；R.sup.5a和R.sup.6a与它们连接的碳原子一起可以形成含有2-5个亚甲基的融合的4-7成员环；X是氧或硫原子。
• 2-Aryl-5,6-dihydropyrimidinones and herbicidal use thereof
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0733622A1

  公开（公告）日：1996-09-25

  A class of 2-aryl-5,6-dihydropyrimidinones and compositions thereof which are useful in the control of weeds is of the general formula wherein    Ar is a substituted or unsubstituted aryl or heteroaryl;    R3 is an optionally substituted alkyl, alkenyl or alkynyl;    R5a and R5b are each independently a hydrogen atom, halo, cyano or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthio;    R6a and R6b are each independently a hydrogen atom, halo, cyano, an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthioalkyl, cycloalkyl, optionally substituted aryl, aryloxy, heterocyclyl or aralkyl, alkylamino, dialkylamino or dialkylaminocarbonyl;    R5a and R6a taken together with the carbon atoms to which they are attached may form a fused 4-7 member ring containing 2-5 methylenes; and    X is an oxygen or a sulfur atom.

  一类用于控制杂草的 2-芳基-5,6-二氢嘧啶酮及其组合物的通式为 其中 Ar 是取代或未取代的芳基或杂芳基； R3 是任选取代的烷基、烯基或炔基； R5a 和 R5b 各自独立地为氢原子、卤代、氰基或任选取代的烷基、烯基、炔基、烷氧基或硫代烷基； R6a 和 R6b 各自独立地为氢原子、卤代、氰基、任选取代的烷基、烯基、炔基、烷氧基或硫代烷基、环烷基、任选取代的芳基、芳氧基、杂环基或芳基、烷基氨基、二烷基氨基或二烷基氨基羰基； R5a 和 R6a 与它们所连接的碳原子一起可形成一个含有 2-5 个亚甲基的 4-7 个成员的融合环；以及 X 是氧原子或硫原子。
• US5629264A
  申请人：——

  公开号：US5629264A

  公开（公告）日：1997-05-13
• FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND METHOD FOR MANUFACTURING THE SAME
  申请人：UNIMATEC CO., LTD.

  公开号：US20210403455A1

  公开（公告）日：2021-12-30

  A fluorine-containing pyrimidine compound is provided represented by general formula (1), (2), (3), (4), (5), or (6) below. wherein, in the general formulae (1) to (6) above, R represents a hydrocarbon group having 1 to 12 carbon atoms; and X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, —C n F 2n+1 (n is an integer of 1 to 10), a nitro group, a boronate group, —OA 1 , —SO m A 1 (m is an integer of 0 to 3), —NA 1 A 2 , —COOA 1 , or —CONA 1 A 2 , and A 1 and A 2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms.

  提供一种含氟嘧啶化合物，其通式表示为(1)、(2)、(3)、(4)、(5)或(6)，其中，在上述通式(1)到(6)中，R代表具有1到12个碳原子的烃基；X和Y各自独立地表示氢原子、卤素原子、具有1到10个碳原子的烃基、-CnF2n+1(n为1到10的整数)、硝基、硼酸酯基、-OA1、-SOmA1(m为0到3的整数)、-NA1A2、-COOA1或-CONA1A2，其中A1和A2各自独立地表示氢原子或具有1到10个碳原子的烃基。