O³-DL-Methylserin-methylester | 88642-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O³-DL-Methylserin-methylester
• 英文别名: O-Methyl-DL-serin-methylester；Methyl 2-amino-3-methoxypropanoate
• CAS: 88642-84-6
• 化学式: C₅H₁₁NO₃
• mdl: MFCD16142756
• 分子量: 133.147
• InChiKey: YDZUJIKUFFJJBR-UHFFFAOYSA-N

物化性质

• 沸点：
  40 °C(Press: 0.7 Torr)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O³-DL-Methylserin-methylester 在 sodium tungstate 、 双氧水 作用下， 生成 α-Oximino-β-methoxy-propionsaeure-methylester
  参考文献：
  名称：

  Gundermann,K.-D. et al., Chemische Berichte, 1964, vol. 97, p. 647 - 653

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl-2-(Carbobenzyloxyamino)-3-Methoxypropionate 在 palladium on activated charcoal 氢气 作用下， 生成 O³-DL-Methylserin-methylester
  参考文献：
  名称：

  Functionalized amido ketones: new anticonvulsant agents

  摘要：

  We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00434-6

文献信息

• Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones
  作者：Stefan Peukert、Yingchuan Sun、Rui Zhang、Brian Hurley、Mike Sabio、Xiaoyu Shen、Christen Gray、JoAnn Dzink-Fox、Jianshi Tao、Regina Cebula、Sompong Wattanasin

  DOI：10.1016/j.bmcl.2008.02.009

  日期：2008.3

  Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one- 3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure - activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided. (C) 2008 Elsevier Ltd. All rights reserved.
• Studies towards the total synthesis of palau'amine. Formation of 4,5-dihydropyrrole-2-carboxylate intermediates by alkene–enamide ring-closing metathesis
  作者：Jason D. Katz、Larry E. Overman

  DOI：10.1016/j.tet.2004.06.140

  日期：2004.10

  A highly functionalized 4,5-dihydropyrrole-2-carboxylate is assembled by alkene-enamide ring-closing metathesis. Subsequent intramolecular azomethine imine dipolar cycloaddition provides a triazacyclopenta[cd]pentalene intermediate of potential use in a total synthesis of palau'amine. (C) 2004 Elsevier Ltd. All rights reserved.
• Klieger,E.; Schroeder,E., European Journal of Medicinal Chemistry, 1976, vol. 11, p. 283 - 286
  作者：Klieger,E.、Schroeder,E.

  DOI：——

  日期：——
• Functionalized amido ketones: new anticonvulsant agents
  作者：C BEGUIN

  DOI：10.1016/s0968-0896(03)00434-6

  日期：2003.9

  We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity. (C) 2003 Elsevier Ltd. All rights reserved.
• Gundermann,K.-D. et al., Chemische Berichte, 1964, vol. 97, p. 647 - 653
  作者：Gundermann,K.-D. et al.

  DOI：——

  日期：——