(2-((6-chloropyridin-3-yl)methoxy)phenyl)(morpholino)methanone | 1415750-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2-((6-chloropyridin-3-yl)methoxy)phenyl)(morpholino)methanone
• 英文别名: [2-[(6-Chloropyridin-3-yl)methoxy]phenyl]-morpholin-4-ylmethanone；[2-[(6-chloropyridin-3-yl)methoxy]phenyl]-morpholin-4-ylmethanone
• CAS: 1415750-52-5
• 化学式: C₁₇H₁₇ClN₂O₃
• 分子量: 332.787
• InChiKey: QUSWRADWEGNPHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2-((6-chloropyridin-3-yl)methoxy)benzoate 在 4-二甲氨基吡啶 、 氯化亚砜 、 水 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 2.0h， 生成 (2-((6-chloropyridin-3-yl)methoxy)phenyl)(morpholino)methanone
  参考文献：
  名称：

  Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, characterization, and biological evaluation

  摘要：

  A series of novel salicylamide derivatives containing neonicotinoid pharmacophore were designed and synthesized via multi-step reactions. These compounds were characterized by satisfied spectrum analyses mainly including H-1 NMR and ESI-MS. The preliminary bioassays indicated that some of target compounds exhibited excellent insecticidal activities against Heliothis armigera and Plutella xylostella at the dosage of 31.25 mu g/mL.

  DOI：

  10.1007/s00044-012-0380-8

文献信息

• Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, characterization, and biological evaluation
  作者：Shaoyong Ke、Zhigang Zhang、Tong Long、Ying Liang、Ziwen Yang

  DOI：10.1007/s00044-012-0380-8

  日期：2013.8

  A series of novel salicylamide derivatives containing neonicotinoid pharmacophore were designed and synthesized via multi-step reactions. These compounds were characterized by satisfied spectrum analyses mainly including H-1 NMR and ESI-MS. The preliminary bioassays indicated that some of target compounds exhibited excellent insecticidal activities against Heliothis armigera and Plutella xylostella at the dosage of 31.25 mu g/mL.