3,4'-二氯联苯-4-醇 | 53905-31-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,4'-二氯联苯-4-醇
• 英文名称: 3,4'-dichloro-[1,1'-biphenyl]-4-ol
• 英文别名: 3,4'-dichloro-biphenyl-4-ol；2-Chlor-4-(4-chlor-phenyl)-phenol；3.4'-Dichlor-4-hydroxy-biphenyl；3,4'-Dichlor-biphenyl-4-ol；4-Hydroxy-3,4'-dichloro-diphenyl；3,4'-Dichloro-4-biphenylol；2-chloro-4-(4-chlorophenyl)phenol
• CAS: 53905-31-0
• 化学式: C₁₂H₈Cl₂O
• 分子量: 239.101
• InChiKey: UHKLHHYQCUBQDI-UHFFFAOYSA-N

物化性质

• 保留指数：
  1950

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,4'-二氯联苯-4-醇 在 四氯化碳 、 氯 作用下， 生成 4-羟基-3,4',5-三氯联苯
  参考文献：
  名称：

  Studies in the Biphenyl Series. III. The Attempted Chlorination of the Acetate, Benzoate and Benzenesulfonate of 4-(4-Chlorophenyl)-phenol: 2-Chloro-4-(4-chlorophenyl)-phenol¹

  摘要：

  DOI：

  10.1021/ja01248a007
• 作为产物：
  描述：

  4-溴-2-氯苯酚 在 potassium phosphate 、 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 、 丙酮 为溶剂， 反应 20.0h， 生成 3,4'-二氯联苯-4-醇
  参考文献：
  名称：

  Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects"

  摘要：

  Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88%). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis. the biological activities (biofilm inhibition. hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8%), hemolytic (1.32-30.1%) and anti-thrombolytic activities (9.64-42.5%), indicating the potential use of these compounds for pharmaceutical applications.

  DOI：

  10.32383/appdr/78920

文献信息

• [EN] BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE<br/>[FR] DERIVES DE L'IMIDAZOLE BICYCLIQUES DIRIGES CONTRE LES FLAVIVIRIDAE
  申请人：GENELABS TECH INC

  公开号：WO2005012288A1

  公开（公告）日：2005-02-10

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  揭示了用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• Bicyclic heteroaryl derivatives
  申请人：Schmitz Ulrich Franz

  公开号：US20050187390A1

  公开（公告）日：2005-08-25

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明涉及用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR
  申请人：Chu Chang An

  公开号：US20080255198A1

  公开（公告）日：2008-10-16

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.

  本发明涉及公式（I）的化合物，其中R1，R2，R3，R4，m，n，p和s如描述和权利要求中所定义，并且其药学上可接受的盐。该化合物用于治疗和/或预防与糖原合成酶酶的激活相关的疾病，如糖尿病。
• BICYCLIC HETEROARYL DERIVATIVES
  申请人：Schmitz Franz Ulrich

  公开号：US20090081165A1

  公开（公告）日：2009-03-26

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明揭示了用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• The Metalation of Thianthrene and Dibenzo-p-dioxin¹
  作者：Henry Gilman、C. G. Stuckwisch

  DOI：10.1021/ja01248a006

  日期：1943.8