Amino-6 cyano-3 methoxy-2 p-nitrophenyl-4 pyridine | 82420-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Amino-6 cyano-3 methoxy-2 p-nitrophenyl-4 pyridine
• 英文别名: 6-Amino-2-methoxy-4-(4-nitrophenyl)pyridine-3-carbonitrile
• CAS: 82420-62-0
• 化学式: C₁₃H₁₀N₄O₃
• 分子量: 270.247
• InChiKey: SEUKSJZBXGDRQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Amino-6 cyano-3 methoxy-2 p-nitrophenyl-4 pyridine 在 镍 potassium carbonate 、 一水合肼 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 24.67h， 生成 methyl N-[4-(6-amino-3-cyano-2-methoxypyridin-4-yl)phenyl]carbamate
  参考文献：
  名称：

  On the Mechanism of Formation of Pyridines from a,b-Unsaturated Nitriles and Active Cyano Compounds

  摘要：

  The mechanism of formation of pyridines from alpha,beta-unsaturated nitriles and active cyano compounds has been investigated. These processes proceed through a Michael adduct which undergoes a regioselective cyclization to the corresponding heterocyclic compound. The regioselectivity of the heterocyclization processes is justified.

  DOI：

  10.3987/com-95-7182
• 作为产物：
  描述：

  (E)-4-nitrocinnamonitrile 在 p-nitrocinnamonitrile 、 sodium 、 dimsyl sodium 作用下， 以 二甲基亚砜 为溶剂， 反应 36.0h， 生成 Amino-6 cyano-3 methoxy-2 p-nitrophenyl-4 pyridine
  参考文献：
  名称：

  On the Mechanism of Formation of Pyridines from a,b-Unsaturated Nitriles and Active Cyano Compounds

  摘要：

  The mechanism of formation of pyridines from alpha,beta-unsaturated nitriles and active cyano compounds has been investigated. These processes proceed through a Michael adduct which undergoes a regioselective cyclization to the corresponding heterocyclic compound. The regioselectivity of the heterocyclization processes is justified.

  DOI：

  10.3987/com-95-7182

文献信息

• Chacon, Maria, Carmen, del; Pardo, Maria, Carmen, del; Soto, Jose, Luis, Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 421 - 423
  作者：Chacon, Maria, Carmen, del、Pardo, Maria, Carmen, del、Soto, Jose, Luis、Lorente, Antonio、Fuentes, Luis

  DOI：——

  日期：——
• DEL, CARMEN, CHACON, M.;DEL, CARMEN, PARDO, M.;SOTO, J. L.;LORENTE, A.;FU+, J. HETEROCYCL. CHEM., 1982, 19, N 2, 421-423
  作者：DEL, CARMEN, CHACON, M.、DEL, CARMEN, PARDO, M.、SOTO, J. L.、LORENTE, A.、FU+

  DOI：——

  日期：——
• On the Mechanism of Formation of Pyridines from a,b-Unsaturated Nitriles and Active Cyano Compounds
  作者：Antonio Lorente、José L. Alvarez-Barbas、José L. Soto、Pilar Gómez-Sal、Antonio Manzanero

  DOI：10.3987/com-95-7182

  日期：——

  The mechanism of formation of pyridines from alpha,beta-unsaturated nitriles and active cyano compounds has been investigated. These processes proceed through a Michael adduct which undergoes a regioselective cyclization to the corresponding heterocyclic compound. The regioselectivity of the heterocyclization processes is justified.