N-phenyl-N-pivaloylglycine | 166033-86-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-phenyl-N-pivaloylglycine
• 英文别名: 2-[N-(2,2-dimethylpropanoyl)anilino]acetic acid
• CAS: 166033-86-9
• 化学式: C₁₃H₁₇NO₃
• mdl: MFCD10028672
• 分子量: 235.283
• InChiKey: NNQKNRPPDURFPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-phenyl-N-pivaloylglycine 在 盐酸羟胺 、 sodium acetate 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 3-tert-butyl-6-trifluoromethyl-5,6-dihydro-4-phenyl-4H-1,2,4-oxadiazin-6-ol
  参考文献：
  名称：

  Cyclocondensation Reaction of Mesoionic 4-Trifluoroacetyl-1,3-oxazolium-5-olates with Hydroxylamine affording 6-Trifluoromethyl-5,6-dihydro-4H-1,2,4-oxadiazin-6-ols

  摘要：

  Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1) undergo tandem addition of hydroxylamine to afford 6-trifluoromethyl-1,2,4-oxadiazin-6-ols (3) in high yields.

  DOI：

  10.3987/com-12-12627

文献信息

• Synthesis and structures of stable phosphorus zwitterions derived from mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates
  作者：Ryosuke Saijo、Hidemitsu Uno、Shigeki Mori、Masami Kawase

  DOI：10.1039/c6cc01627h

  日期：——

  Trialkyl phosphites were evaluated as phosphorus nucleophiles for addition to mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), thereby producing tetravalent phosphorus zwitterions (2) in good yields. The structure of 2 was determined to be...

  将亚磷酸三烷基酯评估为亲核性4-三氟乙酰基-1,3-恶唑鎓-5-酸酯（1）的磷亲核体，从而以高收率生产四价磷两性离子（2）。确定2的结构为...
• Cyclocondensation Reaction of Mesoionic 4-Trifluoroacetyl-1,3-oxazolium-5-olates with Hydroxylamine affording 6-Trifluoromethyl-5,6-dihydro-4H-1,2,4-oxadiazin-6-ols
  作者：Masami Kawase、Ryosuke Saijo、Ken-ichi Kurihara、Kazuki Akira

  DOI：10.3987/com-12-12627

  日期：——

  Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1) undergo tandem addition of hydroxylamine to afford 6-trifluoromethyl-1,2,4-oxadiazin-6-ols (3) in high yields.