2,5-dichloro-3-(L-γ-glutamylamino)benzoic acid | 1220125-19-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,5-dichloro-3-(L-γ-glutamylamino)benzoic acid
• 英文别名: 2,5-dichloro-3-(L-gamma-glutamylamino)benzoic acid；3-[[(4S)-4-amino-4-carboxybutanoyl]amino]-2,5-dichlorobenzoic acid
• CAS: 1220125-19-8
• 化学式: C₁₂H₁₂Cl₂N₂O₅
• 分子量: 335.144
• InChiKey: BGWYWMAHLYCAMX-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  草灭畏 在 N-羟基-7-氮杂苯并三氮唑 、 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 sodium hydroxide 作用下， 以 正己烷 、 二氯甲烷 、 丙酮 为溶剂， 反应 5.5h， 生成 2,5-dichloro-3-(L-γ-glutamylamino)benzoic acid
  参考文献：
  名称：

  EP2554165

  摘要：

  公开号：

文献信息

• CASR AGONISTS
  申请人：Sugiki Masayuki

  公开号：US20110251418A1

  公开（公告）日：2011-10-13

  By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

  通过搜索具有CaSR激动活性的各种化合物，本发明提供了包含该化合物的CaSR激动剂、制药组合物、预防或治疗腹泻的药剂和增强口感的药剂。更具体地说，本发明提供了包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐的CaSR激动剂、制药组合物、预防或治疗腹泻的药剂和增强口感的药剂。
• GLUTAMATE DERIVATIVES OR SALTS THEREOF
  申请人：AJINOMOTO CO., INC.

  公开号：US20130017603A1

  公开（公告）日：2013-01-17

  Compounds having an excellent CaSR agonist activity are in demand. The invention provides glutamate derivatives or salts thereof, pharmaceutical compositions comprising the glutamate derivatives, preventive or therapeutic agents for diarrhea, hyperparathyroidism or peptic ulcer.

  有出色的CaSR激动剂活性的化合物需求。本发明提供了谷氨酸衍生物或其盐，包括谷氨酸衍生物的药物组合物，用于预防或治疗腹泻，甲状旁腺功能亢进或消化性溃疡的药物。
• PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY
  申请人：AJINOMOTO CO., INC

  公开号：US20130102570A1

  公开（公告）日：2013-04-25

  A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

  提供一种药物，其具有优异的CaSR激动剂作用，可预防或治疗糖尿病或肥胖症，该药物组成物包括由一般式（I）所表示的化合物或其盐。
• Prophylactic agent or therapeutic agent for diabetes or obesity
  申请人：Ajinomoto Co., Inc.

  公开号：US08877739B2

  公开（公告）日：2014-11-04

  A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

  提供了一种具有出色的CaSR激动剂作用的药物，该药物能够预防或治疗糖尿病或肥胖症，其组成物包括按照通式（I）定义的化合物或其盐。
• CaSR agonists
  申请人：Sugiki Masayuki

  公开号：US08796485B2

  公开（公告）日：2014-08-05

  By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

  通过搜索具有CaSR激动活性的各种化合物，本发明提供了包含该化合物的CaSR激动剂、制药组合物、预防或治疗腹泻的剂和味增剂。更具体地说，本发明提供了包含具有CaSR激动活性的谷氨酸衍生物或其药用可接受盐的CaSR激动剂、制药组合物、预防或治疗腹泻的剂和味增剂。