1-(propyl-3-enoxy)carbonyl-(3S)-3-[(1R)-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one | 1426255-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-(propyl-3-enoxy)carbonyl-(3S)-3-[(1R)-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
• 英文别名: prop-2-enyl (3S)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-2-oxoazetidine-1-carboxylate
• CAS: 1426255-36-8
• 化学式: C₁₅H₂₇NO₄Si
• 分子量: 313.469
• InChiKey: BCEKFLSNJOKMOA-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.18
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(propyl-3-enoxy)carbonyl-(3S)-3-[(1R)-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 在 盐酸 、 溶剂黄146 作用下， 以 水 、 乙腈 为溶剂， 反应 3.5h， 以76%的产率得到1-(propyl-3-enoxy)carbonyl-(3S)-3-[(1R)-hydroxyethyl]azetidin-2-one
  参考文献：
  名称：

  An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)

  摘要：

  A series of compound was prepared to clarify the reversible mechanism of beta-lactamic hFAAH inhibitors on the one hand, and to modulate some of their physicochemical parameters on the other hand. In particular, two compounds (4h and 4e) were designed to display a potential good leaving group on the crucial carbonyl with a view to possibly acylating the active serine of the hFAAH catalytic triad. Reversibility studies showed that these two compounds retain the reversible mode of inhibition, suggesting a noncovalent interaction between our beta-lactams and hFAAH. Finally, pharmacological evaluations of bioisosteres of the lead compound (4a, IC50 = 5.3 nM) revealed that log P values and PSA could be optimized without altering the FAAH inhibition (IC50 values from 3.65 nM to 70.9 nM). (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.11.035
• 作为产物：
  描述：

  (1'R,3S)-3-<1'-<(tert-butyldimethylsilyl)oxy>ethyl>azetidin-2-one 、 氯甲酸烯丙酯 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以82%的产率得到1-(propyl-3-enoxy)carbonyl-(3S)-3-[(1R)-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
  参考文献：
  名称：

  An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)

  摘要：

  A series of compound was prepared to clarify the reversible mechanism of beta-lactamic hFAAH inhibitors on the one hand, and to modulate some of their physicochemical parameters on the other hand. In particular, two compounds (4h and 4e) were designed to display a potential good leaving group on the crucial carbonyl with a view to possibly acylating the active serine of the hFAAH catalytic triad. Reversibility studies showed that these two compounds retain the reversible mode of inhibition, suggesting a noncovalent interaction between our beta-lactams and hFAAH. Finally, pharmacological evaluations of bioisosteres of the lead compound (4a, IC50 = 5.3 nM) revealed that log P values and PSA could be optimized without altering the FAAH inhibition (IC50 values from 3.65 nM to 70.9 nM). (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.11.035