Bis(2-acetyloxycarbonylphenyl) decanedioate | 213534-98-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis(2-acetyloxycarbonylphenyl) decanedioate
• CAS: 213534-98-6
• 化学式: C₂₈H₃₀O₁₀
• 分子量: 526.54
• InChiKey: UHVRWTMCXQBKOG-UHFFFAOYSA-N

物化性质

• 沸点：
  687.6±55.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  139
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  癸二酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 生成 Bis(2-acetyloxycarbonylphenyl) decanedioate
  参考文献：
  名称：

  Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)

  摘要：

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.

  DOI：

  10.1021/ma048051u

文献信息

• Synthesis of Polyanhydrides
  申请人：Uhrich Kathryn E.

  公开号：US20080234235A1

  公开（公告）日：2008-09-25

  The present invention provides a method for forming compounds of Formula HO—C(═O)R 1 —X—R 2 —X—R 1 —C(═O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R 1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R 2 is a linking group.

  本发明提供了一种形成化合物的方法，其化学式为HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H，其中化合物(I)可聚合以提供含有治疗活性化合物的聚合物。在本发明的化合物中，每个R1是在聚合物水解后将提供治疗活性化合物的基团；每个X独立地是酯键或酰胺键；R2是一个连接基团。
• [EN] COMPOSITIONS AND METHODS FOR THE INHIBITION OF BONE GROWTH AND RESORPTION<br/>[FR] COMPOSITIONS ET PROCEDES D'INHIBITION DE CROISSANCE ET DE RESORPTION OSSEUSE
  申请人：POLYMERIX CORP

  公开号：WO2005039489A3

  公开（公告）日：2005-06-09
• US7875283B2
  申请人：——

  公开号：US7875283B2

  公开（公告）日：2011-01-25
• Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)
  作者：Almudena Prudencio、Robert C. Schmeltzer、Kathryn E. Uhrich

  DOI：10.1021/ma048051u

  日期：2005.8.1

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.