N-benzyl-2-[2-(3-hydroxyphenyl)-ethyn-1-yl]-4-methyl-1,3-thiazole-5-carboxamide | 1205560-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-benzyl-2-[2-(3-hydroxyphenyl)-ethyn-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
• 英文别名: N-benzyl-2-[2-(3-hydroxyphenyl)ethynyl]-4-methyl-1,3-thiazole-5-carboxamide
• CAS: 1205560-25-3
• 化学式: C₂₀H₁₆N₂O₂S
• 分子量: 348.425
• InChiKey: JXDFFINUPGUWQB-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-benzyl-2-iodo-4-methyl-1,3-thiazole-5-carboxamide 、 3-ethynylphenyl acetate 在 四丁基氟化铵 作用下， 反应 3.0h， 生成 N-benzyl-2-[2-(3-hydroxyphenyl)-ethyn-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
  参考文献：
  名称：

  [EN] THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS
  [FR] DÉRIVÉS DE THIAZOLE EN TANT QU'INHIBITEURS DE STÉAROYL-COA DÉSATURASE

  摘要：

  公开号：

  WO2010007482A3

文献信息

• [EN] TISSUE SELECTIVE STEAROYL-COA DESATURASE 1 INHIBITORS AND CELL BASED SCREENING ASSAY FOR THEIR IDENTIFICATION<br/>[FR] INHIBITEURS DE LA STÉAROYL-COA DÉSATURASE 1 SÉLECTIVE DE TISSU ET ANALYSE DE CRIBLAGE À BASE DE CELLULE POUR LEUR IDENTIFICATION
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2010035052A1

  公开（公告）日：2010-04-01

  The present invention provides a method of treating a disorder treatable by administering a therapeutically effective amount of a tissue selective Stearoyl-CoA Desaturase 1 (SCD-1) modulator to a subject. In one embodiment, the present invention provides a method of treating a disorder treatable by administering a pharmaceutically effective amount of a tissue selective SCD-1 inhibitor to a subject. The invention also provides whole cell based screening assays to identify agents that selectively modulate the activity of SCD-1. This invention further provides whole cell based screening assays to identify agents that differentially inhibit SCD in different body tissues.