4-isopropyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine | 53645-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-isopropyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine
• 英文别名: 1-Phenyl-4-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidine；1-phenyl-4-propan-2-ylpyrazolo[3,4-d]pyrimidine
• CAS: 53645-75-3
• 化学式: C₁₄H₁₄N₄
• 分子量: 238.292
• InChiKey: FLMJWKVIQQAUCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-phenyl-1H-pyrazolo<3,4-d>pyrimidine 5-oxide 以1%的产率得到
  参考文献：
  名称：

  HIGASHINO T.; IWAI Y.; HAYASHI E., CHEM. AND PHARM. BULL. , 1976, 24, NO 12, 3120-3134

  摘要：

  DOI：

文献信息

• ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF
  申请人：INTEGRAL BIOSCIENCES PRIVATE LIMITED

  公开号：US20220135598A1

  公开（公告）日：2022-05-05

  The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.