3,5,3',5'-tetraiodo-thyronine methyl ester | 86154-71-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,5,3',5'-tetraiodo-thyronine methyl ester
• 英文别名: DL-Thyroxin-methylester；3,5,3',5'-Tetrajod-thyronin-methylester；Methyl 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
• CAS: 86154-71-4
• 化学式: C₁₆H₁₃I₄NO₄
• 分子量: 790.902
• InChiKey: ZTSGDCMQRKBJKC-UHFFFAOYSA-N

物化性质

• 沸点：
  547.4±50.0 °C(Predicted)
• 密度：
  2.470±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5,3',5'-tetraiodo-thyronine methyl ester 在 sodium hydroxide 、 苯甲醚 作用下， 生成 N-Acetylthyroxin
  参考文献：
  名称：

  Ashley; Harington, Biochemical Journal, 1929, vol. 23, p. 1180

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-3,5-Diiod-thyronin-methylester 在 甲醇 、 正丁胺 作用下， 生成 3,5,3',5'-tetraiodo-thyronine methyl ester
  参考文献：
  名称：

  169.甲状腺素和有关物质的合成。第六部分 DL-甲状腺素某些衍生物的制备

  摘要：

  DOI：

  10.1039/jr9500000840

文献信息

• PHARMACEUTICAL COMPOSITIONS COMPRISING DIIODOTHYRONINE AND THEIR THERAPEUTIC USE
  申请人：Leverve Xavier

  公开号：US20110028554A1

  公开（公告）日：2011-02-03

  The present invention relates to a pharmaceutical composition comprising, as active substance, at least one hormone chosen among 3,5-diiodothyronine (3,5-T2), 3′,3-diiodothyronine (3′,3-T2), 3′,5-diiodothyronine (3′,5-T2), 3′-iodothyronine (3′-T), 3-iodothyronine (3-T) or 5-iodothyronine (5-T), in association with a pharmaceutically acceptable vehicle.

  本发明涉及一种药物组合物，其包括至少一种激素作为活性物质，所述激素包括3,5-二碘甲状腺素（3,5-T2）、3′,3-二碘甲状腺素（3′,3-T2）、3′,5-二碘甲状腺素（3′,5-T2）、3′-碘甲状腺素（3′-T）、3-碘甲状腺素（3-T）或5-碘甲状腺素（5-T），与药学上可接受的载体相结合。
• BIOTINYLATED THYROXINE
  申请人：KASAGI Noriyuki

  公开号：US20100075435A1

  公开（公告）日：2010-03-25

  A means for conveniently and accurately measuring thyroxine or thyronine present in the blood or the like is provided: a compound represented by general formula (I) below: wherein L represents a linear or branched-chain linker having 5 to 50 total atoms; X represents one or more thyroxines, thyronines, or residues of derivatives thereof, bound to the main chain and/or side chain of the linker represented by L, a conjugate in the form of the above compound bonded to an avidin protein, and an aqueous dispersion including a microparticles the surface of which is modified with the above conjugate.

  本发明提供了一种方便、准确地测量血液或类似物中甲状腺素或甲状腺素的方法：化合物由下式（I）表示：其中L表示具有5至50个总原子的线性或支链连接器；X表示一个或多个甲状腺素、甲状腺酮或其衍生物的残基，与由L表示的连接器的主链和/或侧链结合，上述化合物的共轭物与亲合素蛋白结合，并且包括使用上述共轭物修饰的微粒子表面的水分散体。
• Multilayer analytical element
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0097952A2

  公开（公告）日：1984-01-11

  A multilayer analytical element for fluorometric assay of an analyte contained in an aqueous sample liquid, utilizing a competitive binding reaction to a protein between the analyte and a fluorescent-labelled analyte substance or analogue thereof, which comprises: a porous fibrous or non-fibrous spreading sheet containing a predetermined amount of the fluorescent-labelled analyte substance or analogue thereof; a porous sharing sheet enabling substantial separation of a bound fluorescent-labelled complex (B) of the protein from the free fluorescent-labelled analyte substance or analogue thereof (F); and a reaction sheet containing a predetermined amount of the protein specifically bindable to the analyte fixed therein; being under laminated structure in this order. A slide enclosing the multilayer analytical element and a fluorometric assay employing the multilayer analytical element are also disclosed.

  一种多层分析元件，用于利用分析物与荧光标记的分析物或其类似物之间与蛋白质的竞争性结合反应，对水样液体中所含的分析物进行荧光测定，它包括： 多孔纤维状或非纤维状铺展片，其中含有预定量的荧光标记分析物或其类似物； 多孔共享薄片，使蛋白质的结合荧光标记复合物（B）与游离的荧光标记分析物或其类似物（F）得以充分分离；以及 反应片，其中含有预定量的可与固定在其中的分析物特异性结合的蛋白质； 依次为层状结构。 此外，还公开了封装多层分析元件的载玻片和采用多层分析元件的荧光测定法。
• Method for quantitative analysis of low molecular weight components contained in protein-containing liquid sample
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0100543A1

  公开（公告）日：1984-02-15

  A method for quantitative analysis of low molecular weight components which are contained in a protein-containing liquid sample originating from body fluids and are capable of binding to said protein, characterized by incorporating into the liquid sample a compound having the formula (I): In which M is hydrogen ion, an alkali metal ion, or ammonium ion; X is a straight or branched alkyl, alkanyl, fluorinated alkyl, or fluorinated alkenyl group containing at least 6 carbon atoms, Y is a divalent organic residue: and p is 0 or 1.

  一种定量分析低分子量组分的方法，这些组分包含在来自体液的含蛋白质液体样品中，并能与所述蛋白质结合，其特征是在液体样品中加入具有式(I)的化合物： 其中 M 是氢离子、碱金属离子或铵离子；X 是直链或支链烷基、烷基、氟化烷基或氟化烯基，至少含有 6 个碳原子；Y 是二价有机残基；p 是 0 或 1。
• Enzyme-linked immunoassay, assay kits and pair-binding compounds
  申请人：THE UPJOHN COMPANY

  公开号：EP0117693A2

  公开（公告）日：1984-09-05

  An immunoassay, for measuring the amount of a ligand present in a medium, uses a luciferase-labelled binding pair member selected from a ligand and a receptor, in which the luciferase is linked to the binding pair member via its reactive sulfhydryl group and is thereby reversibly inactivated. A kit, for use in an immunoassay to determine the presence of a ligand in a medium, which comprises a plurality of containers, a first container containing luciferase-labelled receptor or ligand (a purified version of the ligand to be assayed) and a second container containing receptor which may be immobilised. New compounds have a reactive group which can react to cause reversible inactivation of luciferase and a group which can react with one or more sites on a binding receptor or ligand.

  一种用于测量培养基中配体存在量的免疫测定，使用荧光素酶标记的配对结合体，该结合体选自配体和受体，其中荧光素酶通过其活性巯基与配对结合体相连，从而可逆地失活。 用于免疫测定介质中配体存在的试剂盒，由多个容器组成，第一个容器装有荧光素酶标记的受体或配体（待测配体的纯化版本），第二个容器装有可固定的受体。 新化合物具有可导致荧光素酶可逆失活的反应基团，以及可与结合受体或配体上的一个或多个位点发生反应的基团。