(S,9e,11z)-13-hydroxy-9,11-octadecadienoic acid | 114818-05-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S,9e,11z)-13-hydroxy-9,11-octadecadienoic acid
• 英文别名: (9E,11Z,13S)-13-hydroxyoctadeca-9,11-dienoic acid
• CAS: 114818-05-2
• 化学式: C₁₈H₃₂O₃
• 分子量: 296.45
• InChiKey: HNICUWMFWZBIFP-SMJYZRPQSA-N

物化性质

• 沸点：
  422.7±20.0 °C(predicted)
• 密度：
  0.970±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  9,10-dibromodecan-1-ol 在 chromium(VI) oxide 、 bis-triphenylphosphine-palladium(II) chloride 、 sodium hydroxide 、 thexylborane 、 硫酸 、 四丁基氟化铵 、 氨 、 sodium amide 作用下， 以 四氢呋喃 为溶剂， 生成 (S,9e,11z)-13-hydroxy-9,11-octadecadienoic acid
  参考文献：
  名称：

  皮质酸及其几何异构体的对映异构体的合成及其生理活性

  摘要：

  皮质酸的对映异构体及其几何异构体都是高度选择性合成的。发现这些酸对稻瘟病菌的孢子萌发表现出相似的抑制活性。

  DOI：

  10.1016/s0040-4039(00)96431-1

文献信息

• KOBAYASHI, YUICHI;OKAMOTO, SENTARO;SHIMAZAKI, TOSHIYUKI;OCHIAI, YOSHINORI+, TETRAHEDRON LETT., 28,(1987) N 34, 3959-3962
  作者：KOBAYASHI, YUICHI、OKAMOTO, SENTARO、SHIMAZAKI, TOSHIYUKI、OCHIAI, YOSHINORI+

  DOI：——

  日期：——
• TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS
  申请人：Pharmacia Corporation

  公开号：EP1231913A2

  公开（公告）日：2002-08-21
• [EN] TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS<br/>[FR] TRAITEMENT DE TROUBLES INDUITS PAR UNE CYCLOXYGENASE-2 AU MOYEN DE COMPOSES A BASE D'ACIDES GRAS CONJUGUES
  申请人：MONSANTO CO

  公开号：WO2001003688A2

  公开（公告）日：2001-01-18

  This invention is directed to a process for the prevention or treatment of inflammation or other cyclooxygenase-2 mediated disorders. This process comprises administering a conjugated fatty acid to an organism in an amount effective to prevent or treat the cyclooxygenase-2 mediated disorder by inhibiting cyclooxygenase -2. In one embodiment, the process comprises administering a fatty acid compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; m is from 6 to 11; and the sum of n and m is from 13 to 16. In another embodiment, the process comprises administering a fatty acid compound having formula (VI) or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R7 is -OH, -SO¿3?H, -SH, -NH2, -PO3H2, or halogen; v is from 7 to 11; and the sum of v and w is from 11 to 15. This invention is also directed to a process for preparing a fatty acid compound. The process comprises combining a ylide with an aldehyde.
• Synthesis and physiological activities of both enantiomers of coriolic acid and their geometric isomers
  作者：Yuichi Kobayashi、Sentaro Okamoto、Toshiyuki Shimazaki、Yoshinori Ochiai、Fumie Sato

  DOI：10.1016/s0040-4039(00)96431-1

  日期：1987.1

  Both enantiomers of coriolic acid and their geometric isomers are synthesized highly selectively. These acids are found to exhibit similar inhibition activity toward spore germination of rice blast fungus.

  皮质酸的对映异构体及其几何异构体都是高度选择性合成的。发现这些酸对稻瘟病菌的孢子萌发表现出相似的抑制活性。